Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0013421 (dystonia)
 8,418 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Blepharospasm-oromandibular dystonia is characterized by the presence of spasms of the orbicularis oculi (blepharospasm) and of the lower facial or oromandibular muscles. A patient with this syndrome is presented in which a left cerebellopontine angle meningioma appeared to act as a triggering mechanism for the development of this disorder. On the basis of this report, we recommend that physicians search for this tumor in patients with this disorder.
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PMID:Blepharospasm-oromandibular dystonia associated with a left cerebellopontine angle meningioma. 225 4

An elderly female patient had a two-year history of stereotyped spontaneous episodes of retropulsion, associated with head retraction, without loss of consciousness, hypertonia, dystonia, or atonia. Results of neurologic examination were normal. After removal of a right hemispheral cerebellar fibroblastic meningioma, the attacks were no longer observed. Attacks of retropulsion and cerebellar meningioma constitute an unusual clinical association.
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PMID:Attacks of retropulsion and cerebellar meningioma. 669 25

Cervical dystonia was associated with posterior fossa tumors in three patients. The onset of dystonia paralleled the appearance of other focal neurologic signs. All patients had extraaxial tumors located in the cerebellopontine angle that were removed via suboccipital approaches. The tumors were identified as schwannomas arising from the glossopharyngeal nerve and from the vagus/accessory nerves; and a meningioma. Postoperatively, the cervical dystonia improved markedly during a period of 8 years in one patient, and it remitted completely within 1 year in another patient. In the third patient, cervical dystonia persisted. The combination of the clinical findings and the temporal relationship of their appearance suggest a causal association between the posterior fossa tumors and cervical dystonia in three cases. Possible pathogenic mechanisms are reviewed.
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PMID:Cervical dystonia associated with tumors of the posterior fossa. 915 45

The aim of this study is to report the association of diffuse dystonia and tremor in a bilateral and extended lesion of the posterior mesencephalon. After surgery on a meningioma of the upper part of the fourth ventricle, this patient presented with facial dystonia, predominating on orbicularis muscles and peribuccal area, and limb dystonia, with tonic extension of fingers and first toes. The tremor was associated with a rhythmic and most often alternate agonist-antagonist muscular activation, whose frequency varied from 3 to 7 Hz. These disorders were increased by the standing position, voluntary movement, somatosensory stimulations, stress or emotion. Pyramidal and somatosensory tracts were spared. Therapeutic trials showed that both the dystonia and tremor were improved by subcutaneous injection of apomorphine, the dystonia by trihexyphenidyle, and the tremor by carbamazepine and propranolol, but not by levodopa and benserazide. The cerebral blood flow study using HMPAO showed a relatively important activity on the cerebellum, which could play a role in the onset of these disorders.
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PMID:[Dystonia and tremor in bilateral lesion of the posterior mesencephalon and the vermis]. 920 96

A patient presented at the age of 50 years with a right-sided, writing-specific dystonia which settled without treatment. Ten years later she developed focal seizures affecting the right leg and occasionally spreading to the right arm. A left parietal meningioma was removed and 2 years later she developed dystonic movements of her right hand. Gliotic changes were seen on magnetic resonance imaging in the superficial left parietal lobe. Mechanisms involved in the generation of dystonia associated with cortical injury are discussed.
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PMID:Focal dystonia after removal of a parietal meningioma. 1519 17

A 40-year-old Asian female presented with an unusual case of focal hand dystonia caused by contralateral clinoid meningioma. Magnetic resonance imaging showed that the tumor compressed the caudate nucleus, lentiform nucleus, cerebral peduncle, internal capsule, and a large portion of the white matter surrounding the basal ganglia. The tumor was gross totally removed via a frontotemporal approach with zygomatic osteotomy, resulting in cure of the focal hand dystonia. Magnetic resonance imaging after surgery showed that the compression of the surrounding brain was released. This case shows that secondary focal hand dystonia caused by extra-axial brain tumor can be cured by surgical removal.
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PMID:Focal hand dystonia cured by removal of clinoid meningioma-case report-. 2003 42

We describe a 48-year-old woman with putaminal gliosis and a sphenoid wing meningioma at the left, who developed dystonia restricted to cervical regions. We propose the following causal chain: the meningioma led to an occlusion of a lenticulo-striatal branch of the middle cerebral artery that caused ventral putaminal ischemia and finally resulting in symptomatic dystonia. The previously reported relevance of the infarcted regions to the pathophysiology of dystonia supports this assumption. Implications for the diagnostic procedure of dystonia will be discussed.
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PMID:Cervical dystonia caused by focal putaminal ischemia. 2673 55