Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0013421 (dystonia)
 8,418 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The author assessed the results of the test of the triiodothyronine (T3) suppression of the I131 absorption in 10 healthy women, 22 suffering from neurocirculatory dystrophy and 35 patients with diffuse toxic goiter. This test was found to distinctly differentiate the patients with diffuse toxic goiter and healthy persons. Reduction of absorption to the level below 15% of the indicator dose with consideration to the level of the initial absorption could be considered as criterion of the normal I131 absorption in response to the T3 administration. The mean suppression of the absorption in T3 administration in patients with neurocirculatory dystonia (10.7 +/- 1.49%) displayed a significant difference from the level of mean suppression of the absorption in patients with diffuse toxic goiter (58.1 +/- 4.76%). However, in individual patients suffering from neurocirculatory dystonia the I131 absorption by the thyroid gland in T3 administration still exceeded such in healthy persons. Therefore such patients require further observation because of a possible development in them of diffuse toxic goiter.
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PMID:[Criteria of the test of suppression of thyroid uptake of I131 by triiodothyronine]. 124 28

Radiometry of the whole body and its organs was employed to study certain aspects of protein-aminoacid and lipid metabolism in patients with thyroid diseases. Metabolism of human serum 131I-albumin was studied in 12 patients with neurocirculatory dystonia (as a premorbid stage of toxic goiter), in 13 patients with diffuse toxic goiter (in 10 before and after drug therapy) and in 9 controls. 75Se-methionine aminoacid metabolism was investigated in 9 patients with toxic thyroid adenoma and in 13 controls. The body cell mass was determined in 82 patients with thyrotoxicosis by a measurable amount of 40K. These data were compared with those of 249 healthy persons. The assimilation of 131I-oleic acid in the G. I. tract was determined in 6 patients with neurocirculatory dystonia, in 18 patients with thyrotoxicosis (in 5 before and after drug therapy) and in 12 controls. The assimilation of 131I-glycerol trioleate was determined in 6 patients with neurocirculatory dystonia, in 16 patients with thyrotoxicosis (in 3 before and after therapy), in 3 patients with primary hypothyroidism and in 10 controls. An increase in catabolism of labeled albumin, intensification of labeled methionine metabolism at the tissue level, signs of a decrease in the total amount of metabolic albumin in the body were revealed. Intensification of protein metabolism resulted in a decrease in the body cell mass of these patients. After adequate therapy the above indices of protein metabolism in patients with thyrotoxicosis returned to normal. The assimilation of fatty acids and neutral fat was disturbed both in thyrotoxicosis and hypothyroidism.
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PMID:[Whole-body radiometric study of protein and lipid metabolism in thyroid pathology]. 310 11

A comparative analysis of thyroid and calcium regulating functions in the diffuse toxic goiter was performed. At the initial stage TSH reaction to TRH was on a decrease in parallel with a sharp increase in the content of T4 T3. Two-third of the patients revealed an increase in the level of calcitonin resulting in an increase in the ratio of calcitropic hormones. In that case the content of ionized calcium was not increased. In one-third of the patients the level of calcitonin showed a tendency to a decrease in the normal ratio of calcitropic hormones not accompanied by change in the level of ionized calcium. In neurocirculatory dystonia polymorphism of clinical manifestation was accompanied by great variations (both rising and lowering tendencies) of all indices.
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PMID:[Interrelation of the thyroid and calcium-regulating functions in patients with diffuse toxic goiter]. 342 31

Altogether 22 patients with diffuse toxic goiter and 14 with neurocirculatory dystonia, treated with lithium carbonate, were examined. Radioimmunoassay of the blood serum triiodothyronine (T3), thyroxine (T4), and thyrotropic hormone (TTH) was used to evaluate the clinical and functional effect of the drug. Lithium carbonate in a dose of 900-1800 mg daily during 4-6 weeks produced a significant reduction in T3 level; the level of T4 was less reduced, and the TTH concentration increased. The pulse rate of patient diminished. Antithyroid effect of the drug is more expressed in patients with medium severity thyrotoxicosis. No side effects were recorded.
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PMID:[Use of lithium carbonate in the therapy of diffuse toxic goiter]. 680 41

Patients with diffuse toxic goiter and those with vegetative dystonia and paroxysmal permanent disorders are shown to have parasympathetic deficiency and moderate sympathetic insufficiency. In toxic goiter patients hyperhydrosis was accompanied by normal conduction along the vegetative perspiration fibers and a significant increase in foot potential amplitude. In patients having vegetative crises there was reduced conduction along the perspiration fibers. Clinical symptoms of enhanced sympathetic activity in both the diseases can be explained by weak parasympathetic influences and hypersensitivity of peripheral tissues to catecholamines. Spilberger test ascertained high reactive and personal anxiety in both groups. By modified MMPI, toxic goiter patients are characterized by hypochondriac, depressive and anxiety trends. Patients with vegetative crises were prone to demonstrative reactions, hypochondria and anxiety.
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PMID:[A comparative analysis of the function of the autonomic nervous system in patients with thyrotoxicosis and autonomic crises]. 786 41