Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0013395 (dyspepsia)
 4,879 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

RAP is a common and challenging clinical presentation in general pediatrics and pediatric gastroenterology. The differential diagnosis is extensive and growing but dominated by functional disorders for which there are new diagnostic criteria despite the lack of specific confirmatory laboratory markers. Because FRAP, dyspepsia, and IBS are common and defined by clinical criteria, it is now prudent to initiate empiric therapy for suspected functional disorders while performing limited laboratory screening to exclude organic disorders. Using this approach, one is no longer bound to undertake extensive testing in all children with undifferentiated RAP. Alarm symptoms help identify children at greater risk for a specific underlying organic cause to their symptoms and can narrow the focus for diagnostic evaluation. Because of altered family dynamics, interaction with psychological comorbidities, and the child's disabled status, the role of the psychologist is critical in many cases. IBS is the most common single diagnosis in undifferentiated RAP and can be readily identified using the current Rome II criteria. The clinical patterns in children--pain plus altered bowel habits--help differentiate patients into diarrhea-predominant and constipation-predominant subtypes. Although the pathophysiology of IBS is unknown, specific approaches to identify and reduce triggers, pharmacologically reduce bowel spasm, and attenuate neural-pain processing are now commonly used and effective strategies.
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PMID:Differential diagnosis of recurrent abdominal pain: new considerations. 1499 44

Previous studies have revealed that leaf extracts of Glyphaea brevis possess antioxidant activity but the bioactivity and mechanisms of action of its major constituents remain unknown. This study evaluated in vitro antioxidant and free radical scavenging activities of Glyphaea brevis twigs and leaves, and probable toxicity profile, pharmacological activities and mechanisms of action of major phytoconstituents in silico. Phytochemical screening detected saponins, tannins, steroids, anthraquinones, flavonoids, terpenoids and phenolics in the extracts. HPLC fingerprinting revealed major compounds as ferulic, catechuic and coumaric acids. Twig extract contained more flavanols compared to the leaf extract while the leaf extract had more flavonol content. Extract of the twigs demonstrated higher ORAC, TEAC and FRAP compared to the leaf extract. In silico analyses predicted low acute toxicity risk and pharmacological activities which are in agreement with traditional use of the plant in the management of diseases such as dyspepsia, ulcers, chest pains, diarrhea, dysentery and sleeping sickness. The molecular docking studies revealed that coumaric acid and ferulic acid have the best binding for all proteins tested. In summary, Glyphaea brevis twigs possess higher antioxidant activity than the leaves and major constituents showed low toxicological potential and promising biological activities which support its ethnomedical use.
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PMID:Glyphaea brevis - In vitro antioxidant and in silico biological activity of major constituents and molecular docking analyses. 3099 71