Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0013395 (dyspepsia)
 4,879 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Using real-time ultrasonography, we monitored gastric emptying indirectly in 26 cases of non-ulcer dyspepsia (NUD) and 13 healthy adults by determining the anteroposterior gastric measurement of a single section of the stomach in the corpus fundus immediately after drinking 500 ml water and then every 10 min. for five times. The average time for 50% gastric emptying in NUD patients (36.46 +/- 13.13, x +/- s) was longer than that in healthy adults (23.54 +/- 5.93), but the half time of gastric emptying in male with NUD was not significantly different as compared with that in male controls and female patients of NUD.
Zhonghua Nei Ke Za Zhi 1992 Oct
PMID:[Measurement of gastric emptying in non-ulcer dyspepsia]. 130 55

A controlled multi-centre clinical trial was conducted for evaluating the efficacy and safety of cisapride in the treatment of 414 cases of functional dyspepsia with 169 cases as control. Cisapride were given 5mg three times daily for 4 weeks. The results showed that cisapride could significantly improve the symptoms including early satiety, abdominal distention, epigastric pain and nausea. Total efficacy rate of cisapride and placebo were 92.99% and 41.42% respectively. There were statistically significant difference between the two groups. Side-effects are abdominal pain and diarrhoea but most of the patients can endure. The above results indicated that the cisapride was safe and effective in treatment of functional dyspepsia.
Zhonghua Nei Ke Za Zhi 1995 Mar
PMID:[A controlled multi-centre clinical trial on cisapride in treatment of functional dyspepsia]. 764 40

Thirty-two patients of non-ulcer dyspepsia (NUD) with gallbladder hypokinesia treated by oral erythromycin administration 0.125g three times daily for two weeks. Before and after oral erythromycin administration, gallbladder volumes were determined by ultrasound, and plasma motilin concentration were determined by radioimmunoassay. The results showed that before and after oral erythromycin administration, maximal percentage emptying of gallbladder were 48.24 +/- 8.30ml vs 69.74 +/- 10.78ml (P < 0.01), plasma motilin were 361.28 +/- 87.92ng/L vs 394.97 +/- 134.27ng/L (P > 0.05). It is indicated that erythromycin could reduce fasting and postprandial residual gallbladder volumes and increases maximal percentage emptying of gallbladder. It suggests that erythromycin might have an agonist action on the motilin receptor as an agonist action on the motilin receptor as an exogenously administrated motilin.
Zhonghua Nei Ke Za Zhi 1994 Jun
PMID:[Clinical study of erythromycin action on gallbladder motility in patients with non-ulcer dyspepsia]. 786 25

Fasting and postprandial antroduodenal motility was studied with manometry in 39 patients with functional dyspepsia (FD) and 15 healthy volunteers. The results showed that: (1) the interdigestive antral motility was significantly decreased with contractions of lower amplitude and less frequency and the amplitude of duodenal contractions was significantly lower in patients than that in controls; (2) the patients also had a reduced antroduodenal motor response to a solid-liquid test meal; (3) the number of antroduodenal coordinated contractions was significantly less in patients and motor abnormalities such as duodenal phase III- like bursts and early appearing interdigestive migrating motor complex (MMC) were recorded in a minority of patients.
Zhonghua Nei Ke Za Zhi 1995 Aug
PMID:[Fasting and postprandial antroduodenal motility in functional dyspepsia]. 869 13