Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0013395 (dyspepsia)
 4,879 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

One hundred and eighty-five patients were perforated duodenal ulcer were treated at one hospital over the 21-year period which straddled the introduction of H2-receptor antagonists. Of these 107 had simple closure, 58 simple closure with immediate H2-receptor antagonists and 20 immediate definitive surgery. The overall operative mortality rate was 5.4%. The rate of subsequent definitive surgery declined significantly in the years after the introduction of H2-receptor antagonists. Only a minority of those who came to subsequent definitive surgery had done so within the first year, the percentage rising from 16% at 1 year to 43.7% at 10 years. Of the patients treated by simple closure alone, 44.3% had subsequent definitive surgery compared with 24.1% having H2-receptor antagonists in addition, but this difference was not statistically significant using life table analysis. Review of the 104 patients available in 1989 showed no significant differences in symptoms between the treatment groups. The only preoperative predictor of subsequent definitive operation was non-steroidal anti-inflammatory drug consumption which showed a negative correlation. A 3-month history of dyspepsia before perforation did not predict the need for subsequent surgery. The symptomatic results in a different group of patients who had undergone highly selective vagotomy subsequent to a previous perforation were no different from patients treated by simple closure alone or with immediate prescription of H2-receptor antagonists. Bloating, however, was significantly more common after highly selective vagotomy. We believe that perforated duodenal ulcer should be treated by simple closure.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Impact of H2-receptor antagonists on the outcome of treatment of perforated duodenal ulcer. 198 17

A 3-year old boy was referred to a paediatric psychiatry out-patient clinic for major disorders consisting of hyperphagia, intolerance to frustrations and instability since the age of one year, and pica (i.e. the indigestion of non-edible substances) since the age of two years. These symptoms developed in a context of greatly disturbed parent-child relations, predominantly made of ambivalence and inability to define limits and interdictions. Conversations with the family are restoring the parental roles and improving the child's symptoms.
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PMID:[Pica. Anomalies in mother-child relations]. 783 Dec 54

AIM:To detect antibodies against Helicobacter pylori spiral and coccoid antigens in human sera.METHODS:Blood samples were collected from 278 patients with gastric diseases. A 3-day-old culture of H. pylori on chocolate blood agar was used to providespiral form. Synchronous coccoids were cultured in (BHY) (brain heart infusion supplemented with 10% horse serum and 0.4% yeast extract) medium in a chemostat.Antigens from spiral and coccoid form were prepared using acid glycine extraction.Enzyme-linked immunosorbent assay (ELISA) was performed to detect serum IgG anti-bodies against spiral and coccoid forms of H. pylori.RESULTS:Seroprevalence of H. pylori infection was higher in patients with gastric ulcer (79%) and gastric cancer (83%) than those with non-ulcer dyspepsia (NUD)(44%) and other diseases (45%) (P <0.05). IgG antibodies against spiral and coccoid antigens were detected in 50.7% (141/278) and 49.6% (138/278), respectively.CONCLUSION:The spiral and coccoid forms of H.pylori coexist in patients infected with the bacterium.
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PMID:Serum IgG response to differentiated antigens of Helicobacter pylori. 1181 88

The reticular motility in 144 cattle with vagal indigestion was evaluated by ultrasonography; 97 had proximal functional stenosis (reticulo-omasal stenosis) and 47 had distal functional stenosis (pyloric stenosis). A 3.5 MHz linear transducer was used to measure the frequency, amplitude, duration and speed of the reticular contractions per three minutes while the animals were standing and unsedated. The mean (sd) number of contractions per three minutes was 4.3 (2.09) with a range from 0 to 12; nine of the cattle had one or two contractions, 17 had three contractions, 59 had four or five contractions, 37 had more than five contractions and 12 had reticular atony. The cattle with proximal functional stenosis had 4.6 (2.01) contractions per three minutes, significantly more (P<0.05) than those with distal functional stenosis (3.6 [2.16]). The position, contour and size of the reticulum, the amplitude and speed of the contractions and the area surrounding the reticulum did not differ significantly between the two groups.
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PMID:Ultrasonographic evaluation of reticular motility in 144 cattle with vagal indigestion. 1912 15