Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0013395 (dyspepsia)
 4,879 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The aim of the present investigation was to study the clearance of 99mTc-p-butyl IDA in some acute and chronic liver diseases, it being considered that the typical parameters obtained with this method are as indicative as any of the others put forward for the study of liver function using radioisotopes. 46 subjects were examined: 6 with acute hepatitis, 10 with chronic hepatitis, 18 with liver cirrhosis and 12 with dyspepsia but otherwise normal haematochemical tests. Two basic 99mTc-p-butyl IDA clearance parameters, Tu (semi-take up time) and Te (semi-excretion time), were determined plotting the data obtained using a Gamma-Camera on semi-logarithmic paper. Mean Tu values were as follows: 5'06'' +/- 1'24'' in dyspeptics, 12'30'' +/- 6'31'' in subjects with acute hepatitis, 6'30'' +/- 1'45'' in subjects with chronic hepatitis and 13'30'' +/- 4'30'' in subjects with cirrhosis. The values were: 34'30'' +/- 4'30'' in dyspeptics, 49'54'' +/- 2'36'' in subjects with acute hepatitis, 42'24'' +/- 12'24'' in subjects with chronic hepatitis and 65'30'' +/- 39'36'' in subjects with cirrhosis. The Tu parameter was found to be delayed more significantly in cirrhotic patients and less in subjects with acute or chronic hepatitis, compared to dyspeptics with normal haematochemical parameters. Te was significantly delayed in subjects with cirrhosis and acute hepatitis, while there was no difference for subjects with chronic hepatitis. Of the routine haematochemical tests, the albumin/gamma-globulin ratio and unconjugated bilirubin were found to correlate significantly with the Tu parameter, whereas conjugated bilirubin was found to bear a significant correlation to the Te parameter.
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PMID:[Hepatic clearance of 99mTc-p-butyl HIDA in liver diseases. Correlations with routine hematochemical parameters of liver function]. 608 7

A technique for the quantitative assessment of post-prandial duodenogastric bile reflux is described using a single isotopes 99Tcm and a single-channel large-field gamma camera with a data processing system. The stomach is localised with pertechnetate prior to IDA administration and duodenogastric reflux is calculated as the percentage of hepatic IDA output reaching the stomach after correction for background activity and hepatic overlap. The technique has been validated, and used to study reflux in 25 patients with gallstones and in 10 control patients. Gall bladder function was assessed with an oral cholecystogram. Marked reflux (greater than 7%) occurred in 5 out 9 patients with a non-functioning gall bladder but in no controls and in none of 16 patients with gallstones in a functioning gall bladder. When patients were studied again after cholecystectomy, 2 patients with normal functioning gall bladders had developed marked reflux while those with preoperative reflux continued to reflux after cholecystectomy. Symptoms of gallstone dyspepsia before operation were more severe in those with marked reflux than those without. Surgery improved these symptoms even in those who continued to reflux after operation.
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PMID:A single isotope method of post-prandial duodenogastric reflux assessment using 99Tcm-labelled IDA in patients with gallstones. 631 77