Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0013395 (dyspepsia)
 4,879 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Helicobacter pylori appears to cause chronic active gastritis, which is characterized by infiltration by neutrophils. Leukotrienes (LTs), which are both chemotactic and cytotoxic, are produced mainly by neutrophils. We studied LT levels, H. pylori infection and neutrophils infiltration in gastric mucosa of patients with non-ulcer dyspepsia. LT levels of mucosa infected with H. pylori were higher than that in non-infected mucosa. There was a correlation between LT levels and neutrophils infiltration in H. pylori infected mucosa. H. pylori was sensitive to lipoxygenase inhibitor, AA-861, both in vitro and in vivo. Treatment with AA-861 decreased the severity of neutrophil infiltration. LTs may therefore be important in chronic active gastritis associated with H. pylori.
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PMID:[Leukotriene levels of Helicobacter pylori-infected gastric mucosa]. 828 25

Capsaicin, the pungent ingredient in red pepper, has been used since ancient times as a spice, despite the burning sensation associated with its intake. More than 50 years ago, Nikolaus Jancso discovered that capsaicin can selectively stimulate nociceptive primary afferent neurons. The ensuing research established that the neuropharmacological properties of capsaicin are due to its activation of the transient receptor potential ion channel of the vanilloid type 1 (TRPV1). Expressed by primary afferent neurons innervating the gut and other organs, TRPV1 is gated not only by vanilloids such as capsaicin, but also by noxious heat, acidosis and intracellular lipid mediators such as anandamide and lipoxygenase products. Importantly, TRPV1 can be sensitized by acidosis and activation of various pro-algesic pathways. Upregulation of TRPV1 in inflammatory bowel disease and the beneficial effect of TRPV1 downregulation in functional dyspepsia and irritable bladder make this polymodal nociceptor an attractive target of novel therapies for chronic abdominal pain.
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PMID:TRPV1 and the gut: from a tasty receptor for a painful vanilloid to a key player in hyperalgesia. 1546 36