Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0013395 (dyspepsia)
 4,879 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The ingestion of radio-opaque granules during a meal enables the radiological study of gastric emptying under physiological conditions. The evacuation of the granules is well correlated with that of solids. After the development of a pharmaco-clinical model of hyposthenic dyspepsia, this technique was used by the authors to evaluate the influence of Primperan on gastric emptying after a dyspeptogenic meal in 12 volunteers. Following the randomised intravenous injection of either 20 mg of Primperan or a placebo, 5 to 7 minutes before the dyspeptogenic meal, the number of granules remaining in the stomach over time was used to measure the rate of gastric emptying. Primperan significantly accelerated the gastric emptying of the dyspeptogenic meal in comparison with the placebo (p less than 0.01).
 ...
PMID:[Application of an original technic in the evaluation of gastric emptying to the study of primperan]. 403 14

The symptoms of repeatedly swallowing what the patient believes is a postnasal discharge, lump in the throat, and constantly having to clear the throat are commonly encountered in patients who do not show any evidence of sinusitis or organic lesions in the upper gastro-intestinal tract or larynx. It is suggested that incompetence of the lower oesophageal sphincter could lead to the creation of this situation by lowering the pH in the oesophagus and initiating inco-ordinate peristaltic movement. A trial of treatment of 54 patients, selected on a nonrandomized consecutive basis and presenting with the above symptoms, was undertaken, treatment being aimed at increasing the cholinergic activity of the oesophageal smooth muscle and neutralizing acidity. Metoclopramide (Maxolon, Primperan) was the cholinergic agent and polymethylsiloxane aluminium hydroxide (Asilone) was the antacid selected. Results based on symptomatic improvement showed that of 44 patients who reported for the follow-up examination, 35 (83%) had good symptomatic improvement, and 7 (16%) were unchanged. The action of metoclopramide is discussed and some of the literature reviewed. Favourable symptomatic improvement suggests that further trials using this substance, together with a placebo, on a cross-over randomized basis would be worth while. The 'lump in the throat' syndrome can be recognized by the symptom tetrad of: (i) lump in the throat; (ii) repetitive swallowing; (iii) clearing of the throat; and (iv) indigestion.
 ...
PMID:Lump in the throat. 740 30