Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0013395 (dyspepsia)
 4,879 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

34 men over the 1979-81 period received steroid therapy in an effect to overcome antisperm antibodies. 2 different regimens were evaluated: methylprednisolone (MP) and betamethasone. 15 men received MP alone, 7 men received MP and after failure of a full course received betamethasone, and 12 men received betamethasone alone. MP was taken orally at a dose of 96 mg by the husband for the 7 days prior to his wife's menstruation. This regimen was repeated each month until pregnancy occur but not for longer than 6 months. The betamethasone regimen was as follows: 0.5 mg taken orally 4 times daily for 3 days, 0.5 mg twice daily for 2 days, and 0.5 mg once daily for 2 days. This 7-day treatment course was repeated on alternate weeks until a pregnancy occurred but not for longer than 6 months. All patients had serum and seminal plasma samples tested by the tray-slide agglutination test (TAT) and the complement-dependent microimmobilization test (MIT). These tests were performed prior to steroid treatment and after intervals of approximately 3 and 6 months of treatment. Treatment was recommended in all cases where antibodies were present and where it was though these antibodies were the limiting factor; no attempt at randomization was made. In the 34 couples with husband receiving steroid treatment, there were 13 pregnancies within 12 months of the start of treatment. 11 pregnancies proceeded to term with normal delivery, and 2 pregnancies ended in abortion at 8 weeks and 12 weeks. There were highly significant differences between the betamethasone group and the group that received no treatment at 6 and 12 months. The differences were just as significant between the MP group and the group that received no treatment. In the 7 patients who received betamethasone following a failed course of MP, no pregnancies were recorded. In 5 of these 7 couples other factors in 1 or the other partner were involved that were not thought to contraindicate steroid treatment yet may have influenced sterility. The overall results of all the steroid-treated patients, when compared with the other patients, showed significant differences in performance, compared with the expected pregnancy rate both at 6 months and 12 months following the start of treatment. 63% of patients complained of weight gain, dyspepsia, irritability, acne, or tingling sensations. The side effects were less marked with betamethasone than with MP. There were statistically significant falls in serum and seminal plasma TAT titers in the MP group. Although the titers fell in the betamethasone group, only the falls in serum TAT titers reached statistical significance. There was no relationship between whether the antibody titer fell and the occurrence of pregnancy.
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PMID:Treatment with intermittent high dose methylprednisolone or intermittent betamethasone for antisperm antibodies: preliminary communication. 712 44

Oral allergies are underdiagnosed by dental health professionals. Patients with an oral allergy complain of various symptoms such as burning or tingling sensations, with or without oral dryness or loss of taste, or of more general symptoms such as headache, dyspepsia, asthenia, arthralgia, myalgia. The signs of oral allergy include erythema, labial oedema or purpuric patches on the palate, oral ulcers, gingivitis, geographical tongue, angular cheilitis, perioral eczematous eruption, or lichenoid reactions localized on the oral mucosa. There is an increase in the prevalence of oral allergies to metals used in dental materials. Allergy to gold included in dental prosthesis has been well documented since the years eighties. Recently, titanium, used in orthopedic devices and oral implants, considered as an inert material, can induce toxicity or allergic type I or IV reactions. These reactions to titanium could be responsible for unexplained successive failure cases of dental implants in some patients (named "cluster patients"). The risk of an allergy to titanium is increased in patients who are allergic to other metals. In these patients, an evaluation of allergy is recommended, in order to exclude any problem with titanium medical devices. We stress the importance of a multidisciplinary approach to take into account patients with an oral allergy, with participation of specialists from dental and dermatologic fields.
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PMID:[Allergies to dental metals. Titanium: a new allergen]. 2038 51

A 40-year-old gentleman previously fit and well presented to hospital on Christmas day in 2003 with dyspnoea, indigestion and 'pins and needles' down his left arm. Investigations in the emergency department were normal, so the patient was discharged from hospital with a diagnosis of panic attacks. A month later he re-presented to hospital, again with an indigestion-like pain in the chest, worsening dyspnoea, poor exercise tolerance and paroxysmal nocturnal dyspnoea. Myocardial infarction was diagnosed, as well as dilated cardiomyopathy. The patient was subsequently put on the heart transplant register. First he had a pacemaker put in, and 4 months later a defibrillator was inserted which dramatically improved the patient's signs and symptoms. He felt well in himself for 7 years; however began to deteriorate in August 2010. No heart transplants were available at the time, so the patient was offered a ventricular assist device in September 2010. The patient went into kidney failure in December 2010 and haemodialysis was commenced in January 2011. He is currently at home awaiting a double heart and kidney transplant.
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PMID:A man awaiting a double transplant. 2272 43

Anxiety is a common yet frequently overlooked psychiatric symptom in patients with ESRD treated with hemodialysis (HD). Anxiety is characterized by disruptive feelings of uncertainty, dread, and fearfulness. A variety of common medical complaints may be manifestations of an anxiety disorder, including palpitations, tremors, indigestion, numbness/tingling, nervousness, shortness of breath, diaphoresis, and fear. It is essential for the clinician to rule out specific medical conditions, including cardiovascular, pulmonary, and neurologic diseases, before ascribing these symptoms to an anxiety disorder. In addition, there is considerable overlap between the symptoms of anxiety and those of depression and uremia. This psychiatric condition has a significant adverse impact on patients' perception of quality of life. Little is known regarding the prevalence and impact of anxiety disorders in patients with ESRD treated with HD; however, many of the seemingly irrational behaviors of patients, or behaviors which place them in conflict with staff and physicians, such as behavioral noncompliance, may be the expression of an underlying anxiety disorder. In this review, we present three clinical vignettes, highlighting the impact of anxiety disorders in patients with ESRD treated with HD.
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PMID:Anxiety in Patients Treated with Hemodialysis. 2766 Mar 3