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Query: UMLS:C0013395 (dyspepsia)
 4,879 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

One hundred and sixty-seven patients in a single general practice who presented with ulcer-like dyspepsia were offered an upper gastrointestinal fibre endoscopy. Twenty-two patients had a peptic ulcer while only three had a gastric ulcer. One patient had a carcinoma of the cardia, one an adenocarcinoma in the body of the stomach and one a carcinoma at the ampulla of Vater. In another 55 patients the main findings at endoscopy were edema/reddening or erosions in the antral or duodenal mucosa. Endoscopic findings were normal in 46 patients. Malignancies were found only in patients over 50 years of age and only 4 ulcers were seen in patients under 40. The clinical findings of presence of night pain, pain relief after food intake and history of peptic ulcer were more common in patients with an existing peptic ulcer than in those with a normal endoscopy.
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PMID:Endoscopic findings in patients with ulcer-like dyspepsia. 386 Sep 19

A double-blind, placebo-controlled study was carried out in 40 out-patients with endoscopically confirmed hypertrophic or erosive gastritis, without ulcer, to assess the effectiveness and tolerance of treatment with equine antisera (antidiencephalon and anti-stomach tissue). Patients were assigned at random to receive a single dose in suppository form on 2 days a week for 6 weeks of both antisera (anti-diencephalon on Days 1 and 4, anti-stomach tissue on Days 2 and 5) or placebo (saline solution). No other anti-ulcer treatment was allowed except standard antacid tablets, the consumption of which was recorded and used as an evaluation parameter. Endoscopy, haematology and haematochemistry were performed before and after treatment; symptoms (daytime and night-time pain, heartburn and dyspepsia) and possible adverse reactions were scored 0 to 4 in order of increasing severity before treatment and after 1, 2, 4 and 6 weeks. Five patients in the placebo group had to be withdrawn from the trial at the second week because of therapeutic failure. This proportion was significantly in favour of the antisera group, as was the proportion of patients endoscopically healed and the extent and rate of symptomatic improvement. Concomitant antacid consumption rapidly and significantly decreased in the antisera but not in the placebo group. Signs of intolerance were not observed with either treatment, nor were there any significant alterations in haematology or haematochemistry. In particular, the immune titre of patients did not increase after treatment, thus indicating that the administered heterologous proteins did not elicit an immunization of the patients against horse protein.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:The use of antisera ('Serocytol') in the management of gastritis: a double-blind clinical assessment versus placebo. 390 78

Seven patients with "coeliac axis compression syndrome" are reported. Five were treated surgically, but only two did well. A survey of 200 healthy adults showed epigastric bruits in 6.5%; only one of these had dyspepsia, though dyspepsia was present in 12.5% overall.Caution is urged in attributing a causal relationship between coeliac axis compression and pain and in proceeding to arteriography when compression is suspected on clinical grounds.
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PMID:Experience with coeliac axis compression syndrome. 541 13

A questionnaire was sent to 5,100 members of the Ileostomy Association of Great Britain and Ireland inviting the members to record their experiences in relation to the function of the ileostomy following on the ingestion of 29 named articles of diet. Nine hundred and fifty-two people, 623 females (65.4%) and 329 males (34.6%), completed the questionnaire satisfactorily. The group showed a close similarity to the total distribution found by the Association with regard to age, sex, and duration of ileostomy. Analysis of the data showed that the great majority of patients with an ileostomy have no difficulty in choosing a diet. The effects of various items of diet on functions of the ileostomy are analysed with special reference to the production of watery flow, upset of timing of filling of the bag, flatulence, pain, and odour. It is concluded that an individual patient with an ileostomy should not omit any article from his diet unless he has found that it repeatedly causes dyspepsia.
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PMID:The effect of diet on ileostomy function. 543 Mar 73

This article describes a data handling system designed to assess the effects of acupuncture in some common diseases. The objectives of this system are to provide a simple, swift and practical method that can be effectively operated within the limits of a busy clinic. This would provide crude descriptive data that will be of use in itself as well as suggesting further ideas for more detailed research. The system is based on the use of simple questionnaires, these are formulated so that they can be used by the patients alone. An initial form is used to record basic patient data and then one of the five symptom group forms (pain, headache, indigestion, lower bowel disorder and breathlessness) is then used to evaluate the severity of any particular disease. All the questionnaires are based on similar criteria, such as drug intake, sleep disturbance due to the disease and patient's subjective evaluation of the severity of their disease. The symptom group forms are filled in by the patient at the beginning of treatment, at the end of treatment and after a three month follow-up period. The questionnaires have been piloted on some 300 patients, and have been found to be a valid and effective method of assessing treatment.
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PMID:A method of assessing the clinical effects of acupuncture. 612 86

Fifty-eight patients with uncomplicated diverticular disease of the colon took bran crispbread, ispaghula drink, and placebo for four months each in a randomised, cross-over, double-blind controlled trial. Assessments were made subjectively, using a monthly self-administered questionnaire, and objectively, by examining a seven-day stool collection at the end of each treatment period. In terms of a pain score, lower bowel symptom score (the pain score and sensation of incomplete emptying, straining, stool consistency, flatus, and aperients taken), and total symptom score (belching, nausea, vomiting, dyspepsia, and abdominal distension) fibre supplementation conferred no benefit. Symptoms of constipation, however, when assessed alone, were significantly relieved. Both fibre regimens produced the expected changes in stool weight, consistency, and frequency. It is concluded that dietary fibre supplements in the commonly used doses do no more than relieve constipation. Perhaps the impression that fibre helps diverticular disease is simply a manifestation of Western civilisation's obsession with the need for regular frequent defecation.
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PMID:Are fibre supplements really necessary in diverticular disease of the colon? A controlled clinical trial. 626 96

Infections with Entamoeba histolytica do not necessarily cause disease in those infected. The parasite may act as commensal (cysts living in the bowel) or it may cause a broad spectrum of clinical illness. Some of the factors causing overt disease are poorly understood. An acute amebic dysentery is accompanied by bloody stools, abdominal pain and indigestion. The most important extraintestinal complication of an amebic infection is a liver abscess causing severe pain, fever, nausea and vomiting. The diagnosis of an amebic infection is based upon isolation of the parasite from the stools. Extraintestinal amebiasis is diagnosed - apart from the clinical picture - by serology. For treatment of intestinal amebiasis so-called contact-amebicides can be recommended. An amebic abscess of the liver usually responds well to dehydroemetine, metronidazole or any other derivative or imidazole and chloroquine. Surgical treatment of amebic liver abscess is only required if complications arise.
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PMID:[Amebiasis]. 628 39

A double-blind trial was carried out in 24 patients with osteoarthritis of the knee or hip to compare the efficacy and tolerance of oxaprozin with that of naproxen. Patients were assigned at random to receive fixed doses of either 1200 mg oxaprozin once daily or 250 mg naproxen 3-times daily over a period of 8 weeks. Assessments made on entry and after 4 and 8 weeks of treatment showed that in the oxaprozin group there were significant mean decreases, indicating improvement in patient's condition, with respect to observer's opinion, patient's opinion, pain intensity and activity impairment at both on-therapy visits. In the naproxen group, there were significant mean decreases with respect to observer's opinion, patient's opinion, pain intensity and time to walk 15 metres. None of the mean differences between the groups was statistically significant. Adverse effects were reported for 3 of the 12 oxaprozin patients and 6 of the 12 naproxen patients. The specific adverse effects noted for more than 1 patient were diarrhoea for oxaprozin and dyspepsia for naproxen. No difference between the groups was statistically significant from this point of view. Laboratory determinations showed no toxicity in either group. It is concluded that once-daily oxaprozin is an effective and well-tolerated form of treatment for osteoarthritis, equivalent to naproxen given 3-times daily.
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PMID:A double-blind, parallel trial of oxaprozin versus naproxen in the treatment of osteoarthritis. 637 52

A prospective, randomized, controlled trial was performed to study truncal vagotomy and drainage (TV), selective vagotomy and drainage (SV) and parietal cell vagotomy (PCV) as elective treatment for duodenal ulcer. Five years postoperatively, 233 patients were available for study: 73 TV, 81 SV and 79 PCV. The ulcer recurrence rates were 13.6, 19.8 and 30.4 per cent respectively. The incidence of severe dumping was 4.9, 10.9 and 1.9 per cent; of severe diarrhoea 4.9, 6.3 and 1.9 per cent; of severe pain/dyspepsia 3.3, 6.3 and 3.8 per cent and of severe nausea/vomiting 0, 1.6 and 0 per cent respectively. Women suffered more postvagotomy symptoms than men. After treatment of recurrences and postvagotomy symptoms, more patients after PCV achieved excellent results than after TV and SV, as recurrences were easier to treat than severe postvagotomy symptoms. The only factor found contributing to the high ulcer recurrence following PCV was the large number of surgical trainees operating in the trial.
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PMID:Prospective controlled vagotomy trial for duodenal ulcer: results after five years. 637 9

Painful epigastric syndrome where gastroenteric or extra-digestive lesions are not revealed by common investigatory techniques (x-rays, endoscopy) are often diagnosed as primary or functional dyspepsia. This review is important because about half of the sufferers complain of functional gastroenteric disorders. The term "Dyspepsia" is reviewed on the basis of old and more recent literature together with long personal experience. The overall results confirm the existence of Dyspepsia as a separate complaint in its own right. The importance of Dyspepsia should be fully understood since a correct diagnosis avoids the need of further checks and choice of pharmaceutical treatment is made easier. Support psychotherapy and diet revision are also facilitated.
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PMID:[A difficult diagnosis: dyspepsia]. 662 4


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