Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0013395 (dyspepsia)
 4,879 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Esophageal squamous papilloma (ESP) is considered to be a rare finding during endoscopy or autopsy. Over a 10 year period, 10 cases were identified among 14,232 patients who were endoscoped in the King Khalid University Hospital (KKUH), Riyadh. The calculated incidence was 0.07%. There were eight males and two females whose ages ranged from 24 to 65 years. The presenting symptoms were mostly dyspepsia and heartburn. All the ESPs were single growth, most of which were located in the lower segment of the esophagus. Immunoperoxidase staining was negative for human papilloma virus in all the tissue samples. It is calculated that ESPs may not be very rare in the Saudi population. Awareness of its occurrence may lead to increasing diagnosis among endoscopy patients.
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PMID:Squamous papilloma of the esophagus - a clinicopathologic study of 10 cases and review of the literature. 1758 24

It is known that the predisposition to human disease is a mixture of inherited susceptibility and acquired exposure to environmental factors. Understanding gastrointestinal disease has indicated that germline adenomatous polyposis coli mutations predispose with a 99% certainty to colorectal cancer, whereas squamous esophageal cancer is caused by a combination of environmental exposures (including alcohol consumption, cigarette smoke, ingestion of contaminated preserved food) and/or infection (specifically with human papilloma virus), in most cases. Until now, despite the reasonably strong evidence for genetic risk from monozygotic twin studies for gastro-esophageal reflux disease (GERD), there have been no documented genetic targets in GERD. In this edition of the Journal, there is intriguing evidence that a common, single base-pair change in the secondary messenger gene GNbeta3 (i.e., a single-nucleotide polymorphism) may be important, perhaps through promoting abnormal perception of visceral pain in the esophagus. Other works link this genetic factor to functional dyspepsia, and these exciting preliminary lines of evidence are reviewed.
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PMID:Dissecting GI phenotype-genotype relationships in GERD and dyspepsia: an SNP here and an SNP there! 1917 93