Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0013395 (dyspepsia)
 4,879 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Gastric lymphoma is an uncommon condition, usually presenting with epigastric pain and/or dyspepsia. There is now good evidence that infection with Helicobacter pylori (Hp) is etiologically important. We report here a case of primary gastric lymphoma presenting with vitamin B12 deficiency anemia and achlorhydria in which there was evidence of previous, but not current, infection with Hp. Vitamin B12 deficiency was proven to be due to intrinsic factor deficiency. To our knowledge, this condition has not previously been reported.
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PMID:Primary gastric lymphoma presenting with vitamin B12 deficiency and achlorhydria. 894 96

The stomach is the most frequent site of extranodal lymphoma. Gastric lymphoma originating from mucosa-associated lymphoid tissue (MALT) is typically a low-grade, B-cell neoplasia strongly associated with Helicobacter pylori (H. pylori) infection. Only certain H. pylori strains in some predisposed patients determine lymphoma development in the stomach, according to a strain-host-organ specific process. The clinical presentation is poorly specific, symptoms ranging from vague dyspepsia to alarm symptoms. Similarly, different endoscopy patterns have been described for gastric lymphoma. H. pylori eradication is advised as first-line therapy in early stage disease, and complete lymphoma remission is achieved in 75% of cases. Neoplasia stage, depth of infiltration in the gastric wall, presence of the API2-MALT1 translocation, localization in the stomach, and patient ethnicity have been identified as predictors of remission. Recent data suggests that H. pylori eradication therapy may be successful for gastric lymphoma treatment also in a small subgroup (15%) of H. pylori-negative patients. The overall 5-year survival and disease-free survival rates are as high as 90% and 75%, respectively. Management of patients who failed to achieve lymphoma remission following H. pylori eradication include radiotherapy, chemotherapy and, in selected cases, surgery.
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PMID:Gastric MALT lymphoma: old and new insights. 2471 39