Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0013395 (dyspepsia)
 4,879 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Benign tumors of the small bowel are rare. They present with many different manifestations depending on the size and location, and also cause a variety of symptoms that are often nonspecific. These include abdominal pain, dyspepsia, nausea, vomiting, and gastrointestinal bleeding that may be melena or hematemesis. Most of the time patients are asymptomatic and the lesions are discovered as an incidental finding. When bleeding occurs, and it may be severe in certain situations, the patient may develop signs of anemia, such as dyspnea, fatigue, and even high-output cardiac failure. The authors present a patient who was evaluated for melena and who was found to have a duodenal polyp that proved to be a Brunner's gland adenoma on pathology.
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PMID:A Brunner's gland adenoma as a cause of anemia. 1047 86

Brunner's gland hyperplasia rarely is associated with clinical problems, and it accounts for only about 10% of benign tumors of duodenum. Therapeutic intervention is indicated when Brunner's gland hyperplasia evokes symptoms such as indigestion, bleeding, or obstruction. Endoscopic intervention (esophagogastroduodenoscopy) often can be used effectively, and in some cases may be preferable because of its minimal invasivencss. However, when the lesion is too large to pass through the endoscopic snare, endoscopic treatment is not possible. In these cases, a laparoscopic procedure may provide a novel approach to resection of the polyp, while still serving as a minimally invasive approach. We report the case of a 28-year-old woman with a large duodenal polyp treated by laparoscopic polypectomy.
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PMID:Duodenal polypectomy of Brunner's gland hyperplasia using a novel laparoscopic technique. A case report. 1214 Jun 25

Mantle cell lymphoma is a very aggressive lymphoma with a very poor prognosis. It commonly involves the gastrointestinal tract but rarely presents as primary gastrointestinal lymphoma. The most notable cases of primary gastrointestinal mantle cell lymphomas have been described as multiple lymphomatous polyposis and have a very poor prognosis. We report a case of primary gastrointestinal mantle cell lymphoma that was discovered by endoscopic biopsy of a single duodenal polyp in a 70-year-old woman who was previously treated for Helicobacter pylori gastritis. She presented with a 6-month history of indigestion, heartburn and abdominal bloating. A subsequent workup revealed one extranodal site of involvement, lymphatic involvement below the diaphragm and a normal bone marrow biopsy. We followed a wait-and-watch approach including serial CT scans and blood tests. Two years later, her symptoms have not progressed and her disease has remained stable.
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PMID:Mantle cell lymphoma: a rare cause of a solitary duodenal mass. 2475 5