Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0013395 (dyspepsia)
 4,879 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 38-year-old man with a history of colonic and small bowel polyposis and glioblastoma was investigated for dyspepsia. Upper GI endoscopy identified an abnormal area in the duodenum, confirmed by histology as high grade non-Hodgkin's B cell MALT lymphoma. Although cases of Turcot's syndrome (TS) (colonic polyposis and primary brain tumour occurring in the same patient) have been previously described, association with haematological malignancy is rare. This is the first report of intestinal lymphoma occurring in an adult with TS.
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PMID:An unusual case of Turcot's syndrome associated with ileal adenocarcinoma, intestinal non-Hodgkin's lymphoma, and duodenal adenocarcinoma. Review of the classification and genetic basis of Turcot's syndrome. 1595 65

This is a case report of a 66-year-old woman who consulted us with a 1-week history of postprandial epigastric discomfort and dyspepsia. Upper and lower gastrointestinal endoscopy and double-balloon enteroscopy revealed lesions in three parts: a swelling with a shallow depression in the ampulla of Vater, flat and rough nodules in the jejunum, and a mixture of lymphoid polyposis and rough surface of follicular lymphoma of the terminal ileum and Bauhin valve. The histological, immunophenotypic, and molecular findings of the duodenal lesion confirmed the diagnosis of follicular lymphoma. We initially diagnosed the ileal lesion as MALT lymphoma immunohistochemically. However, Southern blot hybridization analysis for immunoglobulin heavy chain gene rearrangement showed identical monoclonal bands in both the duodenal and ileal lesions. The molecular cytogenetic studies were also positive for the 14;18 translocation in both lesions. Therefore, the true diagnosis of this ileal lesion should be a follicular lymphoma with marginal zone differentiation. Primary follicular lymphomas of gastrointestinal tract were suggested to have intermediate features between nodal follicular lymphoma and MALT lymphoma. This case is an important clue to prove the similarity of follicular lymphoma of gastrointestinal tract to MALT lymphoma and will be crucial in considering the therapeutic strategy.
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PMID:A duodenal follicular lymphoma associated with the lesion mimicking MALT lymphoma in terminal ileum and Bauhin valve. 2085 67

We describe the clinical scenario of a young male with history of non ulcer dyspepsia who had endoscopic evidence of gastric polyposis in antral area. The polyps disappeared four months after proton pump inhibitors were stopped. Proton pump inhibitors have been linked to gastric fundal polyposis and not antral gland polyposis. This is the first report originating from an Asian country describing antral gland polyposis (AGPs) in a patient on long-term PPI therapy with no evidence of Helicobacter pylori. A case report with brief review is presented.
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PMID:A case of gastric polyposis in antral area of stomach following prolonged proton-pump therapy. 2093 Sep 29

Mantle cell lymphoma is a very aggressive lymphoma with a very poor prognosis. It commonly involves the gastrointestinal tract but rarely presents as primary gastrointestinal lymphoma. The most notable cases of primary gastrointestinal mantle cell lymphomas have been described as multiple lymphomatous polyposis and have a very poor prognosis. We report a case of primary gastrointestinal mantle cell lymphoma that was discovered by endoscopic biopsy of a single duodenal polyp in a 70-year-old woman who was previously treated for Helicobacter pylori gastritis. She presented with a 6-month history of indigestion, heartburn and abdominal bloating. A subsequent workup revealed one extranodal site of involvement, lymphatic involvement below the diaphragm and a normal bone marrow biopsy. We followed a wait-and-watch approach including serial CT scans and blood tests. Two years later, her symptoms have not progressed and her disease has remained stable.
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PMID:Mantle cell lymphoma: a rare cause of a solitary duodenal mass. 2475 5

Cronkhite-Canada syndrome (CCS) is a rare non-heritable condition characterized by gastrointestinal polyposis, dysgeusia, malnutrition, total alopecia and onychodystrophia. Two Danish cases of CCS (an 88-year-old female and a 69-year-old male) presented with signs of malnutrition, dyspepsia, vomiting, dysgeusia and hair loss. An upper endoscopy revealed marked oedema and polyposis in the stomach. Both patients developed colonic adenocarcinomas which were radically operated. Treatment consisted of hyperalimentation, prednisolone and azathioprine. Both patients went into remission - the first patient totally.
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PMID:[Two cases of the rare Cronkhite-Canada syndrome]. 2868 46

Dear Editor, We present the case of a 42-year-old woman under study for dyspepsia without response to empirical treatment. She has perioral mucocutaneous pigmentation. Gastroscopy reveals a 5cm gastric tumor in the antrum, as well as multiple sessile gastric and duodenal polyps smaller than 1 cm (fig 1a). Obtaining large-capacity forceps biopsies, a well-differentiated adenocarcinoma with gastric origin is diagnosed, with over expression of the HER2/neu without microsatellite instability in the context of a hamartomatous polyposis. The genomic study confirms an alteration in the STK11 gene translated to a truncated protein product, compatible with a Peutz-Jeghers syndrome (PJS). In the endoscopic ultrasound study the lesion appears as a heteroecogenic mass with anechoic areas and microcalcifications, arising from the superficial layers of the gastric wall, respecting the muscular layer. The lesion contacts without infiltrating the pancreatic parenchyma which is normal (fig 1b). The study is completed by small-bowel capsule endoscopy (CE) in which multiple micropolyps are observed all along the duodenum, jejunum and ileum; detecting several of them larger than 10mm in the proximal jejunum and the ileum. CT scan shows lymph node and peritoneal involvement. Given the extension, systemic therapy is started with partial response. It is decided to perform cytoreductive surgery (total gastrectomy, right hemicolectomy due to wall implants and resection of distal ileum due to larger than 10mm polyps) and large polyps mucosectomy in the proximal jejunum by anterograde enteroscopy, after which a second-line chemotherapy is started. Discussion PJS is a hamartomatous polyposis that is characterized by a high cumulative risk of cancer in different locations; although gastric malignancy (adenocarcinoma), as in the case we present, is not the most common (1-2). In this type of polyposis, it is important to study the small bowel using CE to define number, location and size of the polyps, as well as identifying the enteroscopy access route which is indicated in symptomatic patients, polyps larger than 10mm or rapid growth (2-4).
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PMID:PRIMARY GASTRIC ADENOCARCINOMA IN PATIENT WITH PEUTZ-JEGHERS SYNDROME. 3324 76