Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0013395 (dyspepsia)
 4,879 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We showed the data on clinical efficiency of low doses of antibodies to brain-specific protein S100 in the complex therapy of schoolchildren with painful variant of functional dyspepsia syndrome. Significant positive effects of the substance on the dynamics of epigastric pain, in particular, its duration, were found. The maximum clinical effect was observed in children with emotional disorders (~1/3 of all examined children). Along with significant decrease in frequency appearance and duration of pain syndrome, the substance also normalized emotional state and improved attention concentration in children.
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PMID:Efficiency of Very Low Doses of Antibodies to S100 Protein in the Complex Therapy of Functional Dyspepsia in Children. 2621 8

Schwannoma rarely occurs in the stomach. We present a case of gastric schwannoma, which was initially evaluated by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) biopsy and confirmed by surgical resection. The patient was a 57-years-old woman with history of dyspepsia, who was found to have a large submucosal mass in the stomach. EUS-FNA showed scant spindle cells with abundant lymphocytes. The spindle cells were immunoreactive with S100, while negative for CD117, desmin, and CD34. The lymphocytes were mixed B-cells and T-cells. Immunostaining, flow cytometry, and molecular testing showed no evidence of B-cell lymphoma. The diagnosis of gastric schwannoma was confirmed by histopathological evaluation of the resected tumor. Gastric schwannoma has unique features of mixed spindle cells and lymphocytes. The tumor should be differentiated from other gastric mesenchymal tumors, and lymphoproliferative disorder is a pitfall.
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PMID:Endoscopic ultrasound-guided fine-needle aspiration biopsy of gastric schwannoma: Cytomorphologic features and diagnostic pitfalls. 3134 12