Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0013395 (dyspepsia)
 4,879 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

There are reports of a hitherto unknown bovine disease in Germany. The symptoms are, in general, indigestion (constipation alternating with diarrhoea), non-infectious chronic laminitis, engorged veins, oedemas, retracted abdomen, emaciation and apathy. Most cases occur during the peripartal period and often result in unexpected death. In addition, there are findings of delayed growth and wasting in heifers, as well as decreasing milk yield. Clinical and standard laboratory examinations leave the origin undisclosed. Bioassays for Clostridium botulinum, its spores and toxins in animals of affected farms revealed the presence of free botulinum toxin in the contents of the lower sections of the intestine. In two control farms without signs of the disease, the tests remained negative. This seems to support our hypothesis that long-lasting absorption of low quantities of botulinum toxin may interfere with the neurological control of intestinal physiology. The authors propose to name this disease complex 'visceral botulism'.
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PMID:Visceral botulism--a new form of bovine Clostridium botulinum toxication. 1155 95

(1) A dyspeptic child rarely, and a baby never, complains of indigestion. It is only from the age of ten years that subjective symptoms sometimes exist. It follows, therefore, that dyspepsia in childhood is often hidden, and has to be searched for in order to be diagnosed.-(2) Dyspepsia in children often takes a misleading form, as it produces a general weakness and wasting, often slight fever, and even coughing. It is therefore frequently confused with tuberculosis.-(3) Dyspepsia in children is a functional complaint, and its cure is therefore almost invariably easy and often rapid.-(4) The different digestive actions depending upon one another, it is usually the first which causes dyspepsia in children. In other words, such dyspepsia originates in the stomach.-(5) In more than three-fourths of the cases this gastric trouble consists of a hyperchloracidity. (6) Treatment is as follows: An approved diet, chiefly consisting of milk and farinaceous foods, a two-hours' rest after meals, and the administration of alkalies. A quick progress towards a complete cure is observed, and, in particular, an increase in weight is very rapid. Statistics drawn up from 200 cases show this, and also that such hyperchloracidity can reach high figures even in very young children.
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PMID:Dyspepsia in Childhood. 1998 22