Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0013395 (dyspepsia)
 4,879 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A patient with dyspepsia and multiple gastric polyps associated with generalized neurofibromatosis is described, and the English literature on generalized neurofibromatosis with gastric involvement is reviewed. Nine patients with gastric neurofibromas have been reported and 2 with one and two gastric polyps respectively, but none with multiple gastric polyps. The commonest presentation has been dyspepsia suggestive of a peptic ulcer.
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PMID:Gastric lesions in generalized neurofibromatosis. 81 82

Progressive anemia, melena, and sudden massive upper gastrointestinal bleeding in a man with cutaneous neurofibromatosis (von Recklinghausen's disease) since childhood prompted endoscopic demonstration of multiple gastric neurofibromas. One source of gastric bleeding removed by endoscopic electrosurgery proved to be a malignant schwannoma (spindle cell sarcoma). A pulmonary schwannoma, multifocal intracerebral spindle cell sarcomas, an extra-adrenal pheochromocytoma, and ocular neurofibromas were other features of this neuroectodermal dysplasia. Neurogenic tumors of the gastrointestinal tract are rare, commonly present with dyspepsia, abdominal pain, anemia, or hemorrhage, and should be suspect in the clinical setting of cutaneous neurofibromatosis. In the patient with systemic neurofibromatosis, endoscopic removal represents a safe method of diagnosis and treatment of bleeding neoplasms in the stomach or duodenum.
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PMID:Gastrointestinal neurofibromatosis. 643 77

The case of a 65 year old man is presented. He had a history of dyspepsia and was diagnosed as neurofibromatosis clinically. Upper G.I. endoscopy showed thickened folds in duodenum. A polyp was seen at the junction of D1 and D2 adjacent to the ampulla. Duodenal biopsy results were suggestive of ganglioneuroma.
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PMID:Ampullary ganglioneuroma: an unusual feature of neurofibromatosis type 1--a case report. 1610 15