Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0013395 (dyspepsia)
 4,879 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A study of the effects of norethisterone enanthate (SH 393) on the endometrium and cervical mucus is presented. 50 women were given a monthly injection of 200 mg SH 393 in 3 series. Withdrawal bleeding at Month 1 was regular, though irregular bleeding occurred at Months 2 and 3 in 90% of the cases. Dyspepsia was the most frequent complaint (12%). Endometrial histology showed both proliferative and secretorial changes in 1 patient 1 month after injection. Biopsies taken in the 2nd and 3rd months usually showed a hypoplastic endometrium with straight tubular glands and no evidence of secretion. Stroma were compact with scanty cytoplasm and some glands showed cystic dilatation. Changes in the cervical mucus revealed a negative ferning pattern in 46 of the 70 cases and some leucocytic infiltration. It is concluded that endometrial suppression and changes in the cervical mucus are main cause s of the antifertility effect of SH 393.
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PMID:Effect of nor-ethisterone enanthate (SH 393) on the structure of the endometrium and on the cervical mucus. 1225 97