Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0013395 (dyspepsia)
 4,879 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In 368 cows with various abomasal disorders--left abomasal displacement (LAD), right abomasal displacement (RAD), abomasal volvulus (AV) and abomasal impaction (vagal indigestion)--the degree of dehydration was compared with electrolytes and acid-base status of the cows. No clinical symptom of dehydration was observed in 62% of cases with LAD and 43% of cases with RAD. The cows were moderately and severely dehydrated in 86% of the cases with AV and 84% with abomasal impaction. Hypochloremic alkalosis was observed in cows with LAD only when the cows were severely dehydrated, but cows with RAD revealed less electrolytes and acid-base abnormalities despite the increase in the dehydration score. In cows with AV, the acid-base status could not be predicted by the degree of dehydration. Profound hypokalemia and hypochloremia were observed in cows with abomasal impaction for all dehydration states. These findings indicated that hypochloremic alkalosis could be predicted in cows with abomasal impaction for all dehydration states and in LAD cases with marked dehydration, but not in RAD cases.
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PMID:Relationship between degree of dehydration and serum electrolytes and acid-base status in cows with various abomasal disorders. 749 42

Sodium bicarbonate is an extremely well-known agent that historically has been used for a variety of medical conditions. Despite the widespread use of oral bicarbonate, little documented toxicity has occurred, and the emergency medicine literature contains no reports of toxicity caused by the ingestion of baking soda. Risks of acute and chronic oral bicarbonate ingestion include metabolic alkalosis, hypernatremia, hypertension, gastric rupture, hyporeninemia, hypokalemia, hypochloremia, intravascular volume depletion, and urinary alkalinization. Abrupt cessation of chronic excessive bicarbonate ingestion may result in hyperkalemia, hypoaldosteronism, volume contraction, and disruption of calcium and phosphorus metabolism. The case of a patient with three hospital admissions in 4 months, all the result of excessive oral intake of bicarbonate for symptomatic relief of dyspepsia is reported. Evaluation and treatment of patients with acute bicarbonate ingestion is discussed.
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PMID:Acute toxicity from baking soda ingestion. 828 75