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Query: UMLS:C0013395 (dyspepsia)
 4,879 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The clinical and radiological features in 30 cases of duodenal tuberculosis are presented. The patients are divisible into two groups on the basis of their presenting features. Twenty-two had symptoms and signs of gastric or duodenal obstruction, and eight patients had dyspepsia suggesting peptic ulceration. In the first group, laporotomy showed that the duodenal obstruction was due to extrinsic compression by matted tuberculous lymph nodes in the majority; there was only five intrinsic strictures. In patients with dyspepsia there were bulbar and post-bulbar ulcers accompanied by more widespread mucosal changes, induration, and periduodenal lymphadenopathy. Bypass procedures were performed to relieve obstruction; no resection was possible because of the adherence of the lymph node masses.
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PMID:Duodenal tuberculosis. 335 96

This report describes the case of a male patient with progressive dysphagia, epigastric pain, odynophagia, generalized weakness and a mid-oesophagus ulceration in which biopsies showed acid-fast bacilli and histological evidence of tuberculosis. Culture of the biopsies and the sputum revealed mycobacterium tuberculosis. There were no respiratory symptoms, and radiographs did not reveal evidence of pulmonary tuberculosis. The patient responded well to antituberculous therapy and he is alive and well 7 years later, without any signs of relapse. The involvement of the oesophagus as the only demonstrable localization of tuberculosis is an extremely rare condition, which should always be considered as differential diagnosis in dyspepsia of unknown origin.
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PMID:Localized tuberculosis of the oesophagus: a rare condition. 760 50

Three groups of children aged 4 to 14 years who complained of having dyspepsia were examined. Group 1 included 31 children without tuberculous infection; Group 2 comprised 30 newly tuberculosis-infected children; Group 3 consisted of 35 children who had an over one-year history of the infection. Esophagoduodenoscopy and biopsy indicated that the incidence of Helicobacter infection and gastritis was higher in children with tuberculous infection than in those without it and it was directly related to the duration of infection. The specific features of chronic gastritis in the infected children were the totality of gastric mucous lesion with more profound antral changes, the predominance of progressive gastritis, as appeared as neutrophilic infiltration, gastric mucous contamination with Helicobacter and Candida, and metaplasia.
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PMID:[Gastroduodenal mucosal morphological changes in tuberculosis-infected children]. 1071 60

In 1999 for the first time the PHLS undertook a questionnaire survey of general practitioners' views of the burden of infectious disease and the priorities for research and development of infectious disease services within the PHLS. Three hundred and seventy-one (38%) of 979 questionnaires mailed to chairs of primary care groups in England, and general practitioners in research networks, were returned. Service areas: computer transfer of laboratory results was considered of greatest priority. Guidance on antibiotic usage, guidance on infectious diseases and education for general practitioners were ranked two, three and four. Burden of infectious disease in primary care: upper respiratory tract infections, tonsillitis/pharyngitis, otitis media/externa and acute cough were placed one, three, four and seven respectively. Urinary tract infections were ranked second and dyspepsia/Helicobacter pylori fifth. Leg ulcers, diarrhoea, genital chlamydia infection and vaginal discharge were other diseases considered to cause a large burden of ill-health. Genital chlamydia, tuberculosis, Helicobacter pylori and meningococci were ranked one, two, three, and five in the NHS opportunity to affect the burden of ill-health. Priorities for improvements to diagnostic tests, evidence on which to base treatment and guidance: chronic fatigue/ME was ranked top in these areas. The other top ten syndromes ranked in order were genital chlamydia infections, antibiotic resistance surveillance, vaginal discharge, leg ulcers, sinusitis, otitis media/externa, dyspepsia/Helicobacter pylori, Creutzfeld Jacob Disease, and tonsillitis. This consultation exercise has highlighted broad areas for future PHLS involvement in primary care. In order to make progress, further consultation is needed with groups of GPs, and other relevant bodies. Particularly for the areas ranked in the top ten, the type of further PHLS involvement needs to be defined. For some syndromes (chronic fatigue and leg ulcers) this may be writing guidance and for others (respiratory tract infections) more treatment trials are required. The purposes and possible methods of communicable disease surveillance in general practice should be the subject of additional consultation.
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PMID:PHLS primary care consultation--infectious disease and primary care research and service development priorities. 1146 14

Though abdominal tuberculosis is fairly common in our country, incidence of tuberculous hepatitis is rare. The authors reported a case who presented to the surgical OPD of the NRS Medical College, Calcutta with complaints of right upper quadrant abdominal pain, flatulent dyspepsia, nausea and occasional vomiting. Ultrasonography (USG) revealed fibrotic gall bladder without any calculus suggesting chronic acalculus cholecystitis. On exploration of the abdomen, the gall bladder was found to be fibrotic and thickened without any calculus. Multiple scarred nodules of different sizes were found in the liver. Cholecystectomy was done and a scarring nodule from the liver was taken for histopathological examination which revealed a tuberculous granuloma. Histopathology of the gall bladder showed cholesterosis. The patient responded to antituberculous drugs.
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PMID:Hepatic tuberculosis--a case report. 1279 46

Antibodies to Helicobacter pylori, Chlamydia spp. and Mycobacterium bovis were determined in patients with coronary heart disease, H. pylori-related dyspepsia, and tuberculosis, and healthy controls. Enzyme-linked immunosorbent assay was conducted with a glycine extract and CagA protein of H. pylori, chlamydial lipopolysaccharide and mycobacterial heat shock protein Hsp65. The prevalence of anti-glycine extract IgG in coronary heart disease patients was higher than in the tuberculosis group and controls, and the same as in dyspeptic patients. Anti-chlamydial IgG were more prevalent in the coronary heart disease group than in healthy subjects. There was no difference in the prevalence of anti-CagA IgG in the coronary heart disease group and controls or anti-Hsp65 IgG in the patients with coronary heart disease, dyspepsia, tuberculosis, and controls. Anti-glycine extract IgA (like anti-glycine extract IgG) were more prevalent in the coronary heart disease group than in the healthy group. The highest anti-glycine extract IgG/IgA and anti-chlamydial IgG titers were more frequent in coronary heart disease patients as compared with controls. Infections with H. pylori and Chlamydia spp. and enhanced production of antibodies to these pathogens may predispose to human atherosclerosis.
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PMID:A link between Helicobacter pylori and/or Chlamydia spp. infections and atherosclerosis. 1273 90

Tuberculosis can involve any part of the gastrointestinal tract and is the sixth most frequent site of extrapulmonary involvement. Both the incidence and severity of abdominal tuberculosis are expected to increase with increasing incidence of HIV infection. Tuberculosis bacteria reach the gastrointestinal tract via haematogenous spread, ingestion of infected sputum, or direct spread from infected contiguous lymph nodes and fallopian tubes. The gross pathology is characterized by transverse ulcers, fibrosis, thickening and stricturing of the bowel wall, enlarged and matted mesenteric lymph nodes, omental thickening, and peritoneal tubercles. Peritoneal tuberculosis occurs in three forms : wet type with ascitis, dry type with adhesions, and fibrotic type with omental thickening and loculated ascites. The most common site of involvement of the gastrointestinal tuberculosis is the ileocaecal region. Ileocaecal and small bowel tuberculosis presents with a palpable mass in the right lower quadrant and/or complications of obstruction, perforation or malabsorption especially in the presence of stricture. Rare clinical presentations include dysphagia, odynophagia and a mid oesophageal ulcer due to oesophageal tuberculosis, dyspepsia and gastric outlet obstruction due to gastroduodenal tuberculosis, lower abdominal pain and haematochezia due to colonic tuberculosis, and annular rectal stricture and multiple perianal fistulae due to rectal and anal involvement. Chest X-rays show evidence of concomitant pulmonary lesions in less than 25 per cent of cases. Useful modalities for investigating a suspected case include small bowel barium meal, barium enema, ultrasonography, computed tomographic scan and colonoscopy. Ascitic fluid examination reveals straw coloured fluid with high protein, serum ascitis albumin gradient less than 1.1 g/dl, predominantly lymphocytic cells, and adenosine deaminase levels above 36 U/l. Laparoscopy is a very useful investigation in doubtful cases. Management is with conventional antitubercular therapy for at least 6 months. The recommended surgical procedures today are conservative and a period of preoperative drug therapy is controversial.
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PMID:Abdominal tuberculosis. 1552 Apr 84

Occupational health problems of 240 male workers of roadways workshop, carriage workshop and battery factory were investigated. Cadmium concentrations in the hair were determined using atomic absorption spectrophotometer. Health effects, such as acidity, hypotension, hypertension, dermatitis, ophthalmic problems, cardiac disease, indigestion, diabetes, tuberculosis, hepatitis B, respiratory troubles, psychological and liver problems were found in subjects. Significant levels between the unhealthy and normal subjects were determined by applying a parametric test, the student's t test at a significant level of p < 0.05. The results of our studies indicate that the significant difference in cadmium levels were observed in subjects suffering from acidity, ophthalmic problems, hypertension, psychological problems, tuberculosis and their respective controls. No correlation with cadmium was obtained with cardiac diseases, diabetes, hepatitis B, respiratory problems, dermatitis and hypotension.
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PMID:Hair as an indicator for assessing adverse effect of cadmium on human health. 1666 37

A 72-year-old postmenopausal woman presented with dyspepsia, weight loss, abdominal pain, and ascites. Ultrasonography revealed a pelvic mass and evidence of pyometra. Serum CA-125 was raised. Paracentesis revealed lymphocytic exudate but no malignant cells or acid-fast bacilli. However, after drainage of pyometra endometrial curettings revealed epithelioid granuloma with acid-fast bacilli. She had complete recovery with full course of antituberculosis treatment. Thus, pelvic tuberculosis should be considered in the differential diagnosis of ovarian malignancy, which can prevent many unnecessary laparotomies.
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PMID:Pelvic tuberculosis in a postmenopausal woman mimicking ovarian malignancy--a clinical dilemma. 1955 90

(1) A dyspeptic child rarely, and a baby never, complains of indigestion. It is only from the age of ten years that subjective symptoms sometimes exist. It follows, therefore, that dyspepsia in childhood is often hidden, and has to be searched for in order to be diagnosed.-(2) Dyspepsia in children often takes a misleading form, as it produces a general weakness and wasting, often slight fever, and even coughing. It is therefore frequently confused with tuberculosis.-(3) Dyspepsia in children is a functional complaint, and its cure is therefore almost invariably easy and often rapid.-(4) The different digestive actions depending upon one another, it is usually the first which causes dyspepsia in children. In other words, such dyspepsia originates in the stomach.-(5) In more than three-fourths of the cases this gastric trouble consists of a hyperchloracidity. (6) Treatment is as follows: An approved diet, chiefly consisting of milk and farinaceous foods, a two-hours' rest after meals, and the administration of alkalies. A quick progress towards a complete cure is observed, and, in particular, an increase in weight is very rapid. Statistics drawn up from 200 cases show this, and also that such hyperchloracidity can reach high figures even in very young children.
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PMID:Dyspepsia in Childhood. 1998 22


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