Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0013395 (dyspepsia)
 4,879 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 61-year-old housewife was diagnosed as having peptic ulcer disease for a period of 2 years. During this time she had episodes of abdominal cramping, dyspepsia, and one episode of severe upper gastrointestinal bleeding. She was subsequently found to have a large gastric lipoma. Gastric lipoma, a rare tumor, frequently mimics peptic ulcer disease in its clinical presentation and its complications. This point has not been previously emphasized.
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PMID:Gastric lipoma presenting as peptic ulcer: case report and review of the literature. 660 87

Lipoma is a benign tumour of mesenchymal origin which is not frequently localized in the gastroenteric tract; in anatomopathological statistics it is less rare: this is due to the fact that it rarely reaches dimensions which warrant surgical treatment. It is usually either an occasional finding during the course of laparotomy due to other motives or is the cause of complications, as in the present case of intestinal occlusion due to ileocolic invagination, resulting in emergency surgery. As a cause of occlusion tumours of the small bowel are second in terms of incidence to adhesive factors, volvuli and hernias. Invaginations account for 2/3 of small bowel occlusions caused by up to 80% of tumours: the lipoma is the most frequent benign tumour to cause invagination in its submucous polypoid and more or less scissile form. Symptoms are not specific and this causes a delay in diagnosis. Patients are often young subjects with a history of recurrent abdominal colic and sensitivity to anti-spastic drugs so much so that in the past they were diagnosed as "chronic colic" sufferers. Sometimes the only symptom is dyspepsia, or nausea and vomiting, or occasionally abdominal distension with constipation or attacks of diarrhoea. Radiology is not of great value in the diagnosis except for indicating the possible need for emergency surgery. There are no radiological tests, with or without contrast mediums, echography, CAT or MNR which can diagnose this pathology. The decision to operate is usually triggered by the presence of a complication, but perioperative extemporary histological tests are advisable for a correct surgical approach: if the form is scissile, segmentary resection of the small bowel is necessary.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Lipoma of the small intestine as a rare cause of intestinal occlusion]. 799 Dec 7

The results of retrospective series counting 178 cases of surgically resected stomach, duodenum and small bowel benign tumours are analysed. It is a Belgian retrospective multicentric study that extend over a mean duration of 7 years 9 months. The main symptoms are haemorrhage, dyspepsia, obstruction and invagination. The most frequent tumours are leiomyoma, adenomatous polyps, lipoma and schwannoma. Preoperative investigations are endoscopy and radiology. To finish off the gastro-duodenal tumours examinations, endoscopy is necessary and arteriography can be helpful in small bowel tumours. Operative mortality of this series is 2.2%; local and general postoperative complications are 34.2%. Observed local recurrence in 118 patients with mean follow-up of 27 months is 1.7%. The authors emphasize the surgical resection necessity of these tumours as their malignant potentiality is not inconsiderable. Considering local recurrence, malign change and afar dissemination, a long-term follow-up is recommended.
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PMID:Benign tumours of the upper gastro-intestinal tract (stomach, duodenum, small bowel): a review of 178 surgical cases. Belgian multicentric study. 847 Apr 42

Gastric lipoma is one of the rare benign gastric tumors. Its preoperative diagnosis obviates the need of an extended gastrectomy. We report a case of gastric lipoma who presented with symptoms of dyspepsia and was treated by surgical gastrectomy and tumour enucleation.
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PMID:Gastric lipoma presenting with dyspepsia. 1272 77

Giant lipomas of the stomach are very rare, accounting for less than 3% of all benign tumors of the stomach. A clear-cut endoscopic differentiation between gastric lipomas and other submucosal neoplasms is not feasible, because routine endoscopic gastric biopsies do not reach the submucosal layer. Gastric submucosal lipomas can cause gastric ulceration as in the case presented below and in rare instances this may in turn promote gastric cancer. Therefore, complete pretreatment diagnostic evaluation is needed. We present a 52-year-old man with a 6-month history of epigastric discomfort, early satiety, decreased appetite, and dyspepsia. His weight was noted to be stable and he was iron deficient (hemoglobin 11.5 g/dl and ferritin of 5 g/dl). His past history included a gastric ulcer found on endoscopy 5 years ago for which he was on omeprazole 40 mg once a day, hypertension, hypercholesterolemia, and diabetes. Clinical examination revealed central obesity with divarification of recti muscles. He underwent a colonoscopy that was normal, and an oesophago-gastro-duodenoscopy that revealed a smooth extrinsic indentation of the anterior aspect of the distal stomach at around 50 cm. Biopsies of this were normal. A computed tomography scan was obtained () that demonstrated a 14 by 15-cm fatty tumor arising from the distal stomach with a couple of 5-mm nodes adjacent to tumor and no distant metastasis representing either a lipoma, liposarcoma or gastrointestinal stromal tumours. He subsequently underwent a subtotal gastrectomy. Macroscopically, the antrum was distorted by a huge submucosal intramural tumor mass. The antral mucosa was stretched over its surface and bore a central 15-mm ulcer surrounded by a raised border (). Microscopic examination confirmed an ulcerated benign submucosal lipoma. Our patient was symptomatic with a large gastric lipoma that necessitated surgical excision. Following surgery his postoperative recovery was uneventful, and he was asymptomatic when reviewed 4 weeks later. This case demonstrates a rare case of gastric lipoma causing gastric epithelial ulceration leading to iron deficiency.
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PMID:A rare case of iron deficiency. 2200 28