Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0013395 (dyspepsia)
 4,879 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Periampullary tumour in two Ethiopian patients are described. The first patient, a 60 year old non-insulin dependent diabetic woman with ampullary adenocarcinoma, presented with symptoms, signs and laboratory results suggestive of obstructive jaundice and iron deficiency anaemia. The second patient, a 40 year old lady with duodenal adenocarcinoma, presented with dyspepsia and weight loss of 15 kilogramme. The clinical presentation, diagnosis, and management of periampullary tumours are discussed with review of the literature.
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PMID:Periampullary tumours: report of two cases. 875 40

Enteric fever due to Salmonella Typhi is a major public health problem. Typhoid carriers have high titres of Vi agglutinins in their sera. We worked out the baseline data for Vi agglutinins from 705 healthy blood donors (controls) by ELISA and compared it with 446 patients with biliary, gastrointestinal and other related diseases (cases). The samples were divided into five groups based on the disease condition of the patients from whom they were collected. Group A (n=196) consisted of patients with stones in the gall bladder/common bile duct and Group B (n=27) with gall bladder carcinoma. Group C (n=33) comprised patients with carcinoma of the pancreas/ampulla, obstructive jaundice and/or cholangiocarcinoma. Group D (n=112) had patients with acute/chronic pancreatitis, abdominal pain, intestinal obstruction, peritonitis, carcinoma oesophagus, chronic diarrhoea, gastrointestinal bleeding and dyspepsia. Group E (n=78) included patients with miscellaneous diseases. The mean absorbance value obtained for healthy subjects +3 standard deviations was taken as the cut-off value for a positive typhoid carrier. In Group A, 10.2% samples were positive; in Group B, 7.4%; in Group C, 12.0%; in Group D, 9.8% and in Group E, 9.0%. There was a highly significant (P <0.001) increase in the presence of Vi agglutinins in the cases compared to the controls. High prevalence of typhoid carriers occurs in patients with biliary, gastrointestinal and other related diseases. Vi serology employing highly purified Vi antigen offers a practical and cost-effective way of screening for S. Typhi carriers.
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PMID:Epidemiology of typhoid carriers among blood donors and patients with biliary, gastrointestinal and other related diseases. 1572 95

Mirizzi syndrome is a rare complication of the long-term gallbladder stone disease. It's caused by a gallbladder stone impression to the common bile duct wall. The clinical appearance is an obstructive jaundice, pain in right subchondrium and dyspepsia. Higher pressure in the extrahepatal bile ducts leads to biliobiliary or enterobiliary fistula formation. In the described case a cholecystoduodenal fistula was found. Preoperative diagnosis of MS is a medical challenge, and majority of the diagnosis is set introperatively. Surgery is the treatment of first choice. Ignoring the possibility of MS can seriously damage patient's health by injuring bile ducts during the surgery.
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PMID:[Mirizzi syndrome with cholecystoduodenal fistula--a rare complication of cholecyctolithiasis]. 1951 24

Ectopic pancreas is an uncommon congenital anomaly, which is usually found incidentally in clinical practice. It presents with nonspecific gastrointestinal symptoms like epigastric pain and dyspepsia and rarely with the clinical findings of obstructive jaundice or intestinal obstruction, or it may mimic gastrointestinal system cancer. Herein, we describe a case of ectopic pancreas in the duodenum, which was the cause of the intractable diarrhea. In our patient, upper gastrointestinal endoscopy and endoscopic ultrasonography revealed a 1.5 cm submucosal lesion, which was umbilicated centrally with a normal in appearance overlying mucosa. Endoscopic biopsy of the lesion was normal. Pathological examination of the lesion after surgical excision was compatible with ectopic pancreas. After total excision of the lesion, the clinical findings of the patient normalized. Ectopic pancreas presenting with diarrhea has not been reported previously in the literature.
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PMID:Ectopic pancreas presenting with intractable diarrhea: case report. 2194 76