Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0013395 (dyspepsia)
 4,879 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Alpha-methyldopa-induced histologic alterations were investigated in 21 patients with hepatic injury after short- and long-term exposure. Seven patients developed liver injury within 6 months and 24 after several years (mean, 5 years) of exposure. Histologic findings and clinical and biochemical data differed significantly in the two groups. Morphologic analysis of the short-term-treated group revealed marked parenchymatous degeneration, focal, confluent and massive necrosis, and inflammation. Fatty accumulation and increased fibrous trabeculae were characteristic for the patients treated for long term. All patients in the short-term-exposed group had acute and severe hepatitis. Four of them had icterus. Two patients died of hepatic coma. Patients in the long-term-treated group had for several months initially mild but increasing discomfort, dyspepsia, nausea, and colics. Liver function tests in these groups revealed differences in serum albumin, bilirubin, and transferase levels. No changes were observed in alkaline phosphatase and Thrombotest. Fat accumulation and fibrous trabeculae suggest that the alterations precede the clinical symptoms and biochemical signs of hepatitis. The findings show that alpha-methyldopa may induce hepatocellular injury after short- and long-term exposure.
 ...
PMID:Morphologic alterations in patients with alpha-methyldopa-induced liver damage after short- and long-term exposure. 732 15

In a 48 year old man suffering from dyspepsia and progressive enlargement of the liver, the clinical suspicion of a malignant cystic disease of the liver was voiced. Six months after the onset of the complaints the disease was diagnosed through a biopsy performed during an operative laporotomy. The patient died in spite of combined antitumorous chemotherapy in some further 7 months in a state of hepatic coma. A detailed pathologico-anatomical examination divulged the picture of a very rare form of carcinoma arising from the membrane covering not only the hepatic cysts but also those in the kidneys. Microscopically it had the structure of a papillary adenocarcinoma. Differential diagnostic variations of this tumour as compared to true neoplastic cysts i. e. cystadenomas or cystadenocarcinomas arising from the lining of hepatic bile ducts, are pointed out in this paper.
 ...
PMID:[Multiple carcinomas arising from congenital cysts of the liver and kidneys]. 732 71