Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0013395 (dyspepsia)
 4,879 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Duodenogastric reflux has a deleterious effect on the gastric mucosa. It was the aim of this study to assess the acute effects of cisapride on antroduodenal motility and duodenogastric reflux in seven patients with severe dyspepsia and increased biliary reflux, as evidenced by increased bile salt output in their gastric aspirates. Each patient underwent two studies on separate days. On each day, after an overnight fast, each patient swallowed a multilumen tube for manometric recording of gastroduodenal motility. Phenol red was infused into the second portion of the duodenum, gastric juice was aspirated, and motor activity was monitored for 90 min. At the end of this period, the patient received either cisapride or placebo intravenously in a double-blind randomized fashion. Antroduodenal motility and duodenogastric reflux were monitored for the subsequent 90 min. A significantly (P less than 0.01) higher motility index was found in the antrum after cisapride (2678 +/- 712 vs 1110 +/- 412 in the basal period) while placebo had no effect. The duodenal motility index was not affected by cisapride or placebo. Bile salt outputs in gastric aspirates were significantly (P less than 0.05) reduced following cisapride injection (0.42 +/- 0.6 mmol vs 1.6 +/- 1.2 mmol during basal period). Conversely, outputs of phenol red in the gastric aspirates were unaffected by cisapride. In conclusion, cisapride stimulates antral motility and decreases biliary reflux in patients with dyspepsia and increased duodenogastric reflux.
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PMID:Cisapride stimulates antral motility and decreases biliary reflux in patients with severe dyspepsia. 274 45

One hundred and two patients suffering from giardiasis and/or chronic gastritis were subjected for upper gastrointestinal endoscopy. Purified immune rabbit's serum against Giardia lamblia was used in ELISA and immunoperoxidase (IIP) techniques for detection of Giardia antigen in the stomach. Results showed that out of 70 cases with intestinal giardiasis, 8 (11.4%) by ELISA and 6 (8.6%) by IIP showed gastric giardiasis. Higher percentage of gastric giardiasis (14%) was encountered in cases with both giardiasis and chronic gastritis (50) than in cases with giardiasis alone (5%) but with statistically insignificant difference (P > 0.05). None of the cases with chronic gastritis alone (without giardiasis) was positive for gastric giardiasis. Dyspepsia was the main presenting symptom in cases with gastric giardiasis (P < 0.05) with significant (P < 0.05) association. Helicobacter pylori was encountered in 6 out of 8 cases (75%) with gastric giardiasis (P < 0.05) with significant (P < 0.05) association. Duodenogastric reflux was detected in 4 out of 8 cases (50%). Histopathological changes in antral mucosa were detected in all cases of gastric giardiasis. This study indicates that under abnormal circumstances most probably with decreased gastric acidity, gastric giardiasis can occur in concomitance with intestinal giardiasis. So, one has to search for Giardia in gastric biopsies, particularly those showing chronic atrophic gastritis and H. pylori. Also, one has to be aware of gastric giardiasis as a possible cause of upper gastrointestinal symptoms.
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PMID:Giardia lamblia and chronic gastritis. 875 56

Duodenogastric reflux (DGR) was assessed with 24-hour gastric bilirubin monitoring in 345 patients (219 men; 49 +/- 13 years) with foregut symptoms and 41 healthy subjects (24 men, 28 +/- 5 years). Bilirubin exposure was measured as percent time above absorbance level 0.25 and excessive DGR was defined above the 95th percentile of normal values (>24.8%). DGR was highest following Billroth II gastric resection (60 +/- 24%, N = 15). Patients after cholecystectomy (28 +/- 25%, N = 25), patients with gastroesophageal reflux disease (24 +/- 24%, N = 199), and patients with nonulcer dyspepsia (23 +/- 21%, N = 61) had a significantly higher exposure to DGR than healthy subjects (7 +/- 8%, P < 0.0001). In conclusion, gastric bilirubin monitoring is useful for the assessment of DGR specifically in symptomatic patients following gastric resection. Increased amounts of DGR may further be of clinical importance in patients with reflux disease or nonulcer dyspepsia and following cholecystectomy.
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PMID:Gastric bilirubin monitoring to assess duodenogastric reflux. 1249

Symptoms of functional dyspepsia demonstrate significant variability, among others dependently on the time of the day and on consumed meals. The aim of the study was to find out whether duodenogastric reflux is observed in subjects with nonulcer (NUD) and dysmotor dyspepsia (DD) and whether its intensification changes within 24 h. Investigations comprised 25 subjects with NUD and 25 with DD, aged 19-43 years after exclusion of other diseases and H. pylori infection. The gastric content of bilirubin was registered with Bilitec 2000 Synectics Medical. Duodenogastric reflux episodes were observed in both groups but their intensification and 24h dynamics were differentiated. In subjects with DD total reflux index was significantly higher than in those with NUD (mean=18.0+/-9.5% and mean=6.3+/-4.1%; p<0.05). These differences were particularly visible in after meal (mean=21.2+/-7.9% and mean=10.4+/-6.6%; p<0.01) and night time (mean=8.7+/-3.6% and mean=2.9+/-0.9%; p<0.01). The results of the study indicate that bilimetry may be useful in differentiation of the form of dyspepsia and in selection of rational therapy.
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PMID:[Assessment of duodenogastric reflux 24h variability in subjects with functional dyspepsia]. 1560 69