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Query: UMLS:C0013395 (dyspepsia)
 4,879 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Systematic studies of psychiatric disorders in non -ulcer dyspepsia are rare. The aim of the present study was to find out the nature and prevalence of psychiatric morbidity in non-ulcer dyspepsia. Thirty three patients with non-ulcer dyspepsia and thirty with duodenal ulcer were assessed for psychiatric morbidity with the help of the regular version of the SADS, and diagnosed according to DSM-IIIR criteria. Non-ulcer dyspepsia was defined precisely and investigators who made the psychiatric diagnosis were blind to the gastroenterological diagnosis. In the non-ulcer dyspepsia group, 69.7% of patients had psychiatric morbidity, compared to 26.7% in the ulcer group. The difference between the two groups in the frequency of psychiatric morbidity was statistically significant. Dysthymic disorder (39.4%) was the most frequent psychiatric disorder in the non-ulcer dyspepsia group.
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PMID:Psychiatric disorders in non - ulcer dyspepsia. 2177 69

The prevalence of psychopathology in patients presenting with functional bowel disorder to the gastroenterology department was determined using formal psychiatric rating scales. There was no evidence of excessive psychiatric disorder compared to a group of patients with peptic ulcer disease. However, greater trait scores for neuroticism and introversion were found in the functional disorder group, together with a greater reporting of life events perceived as negative. Central serotoninergic receptor role in the pathophysiology of functional dyspepsia was assessed using a neuroendocrine challenge test. Buspirone, an azaspirone, stimulates central serotoninergic-1(A) receptors and, as a consequence, releases prolactin, and the extent of prolactin release after the challenge is an indicator of central serotoninergic receptor sensitivity. The mean prolactin response was significantly greater in patients with functional dyspepsia than in healthy controls and peptic ulcer disease patients. The sensitivity of the central serotoninergic receptors was also highly correlated with the degree of delayed solid phase gastric emptying assessed scintigraphically. Finally, dyspeptic symptoms can be reproduced in patients by an intravenous cholecystokinin infusion and severity of response was analysed using a visual analogue scale.
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PMID:Serotonin and physical illness: focus on non-ulcer dyspepsia. 2228 64

We wanted to examine the prevalence of psychiatric morbidity in patients diagnosed as having essential dyspepsia, as well as the short-term course of dyspeptic symptoms, following drug treatment of the psychiatric condition. Seventy-four patients with essential dyspepsia presenting to the gastroenterology outpatient department of a medical college were investigated for the presence of psychiatric disorder. The response to an open trial of pharmacotherapy in 50 patients with a psychiatric disorder and no other demonstrable pathology was assessed. These patients met the criteria for a DSM-III-R diagnosis, most commonly major depressive disorder (26) or generalized anxiety disorder (10). The mean age of those with a psychiatric disorder alone was significantly higher than that of those with another demonstrable pathology. With treatment, 16 patients with no demonstrable pathology other than psychiatric disorder (depression: 12; anxiety: 4) showed improvement over a period of 6 weeks in psychiatric as well as dyspepsia ratings. The difference was however statistically significant only for the group with major depressive disorder. We concluded that, despite differences in the characteristics of the population studied, a psychiatric diagnosis is associated with at least a proportion of cases with essential dyspepsia and emerges as a likely explanation.
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PMID:Psychiatric disorder in essential dyspepsia. 2494 46

Depression is a common mental disorder and the leading cause of disability in the worldwide. Based on Islamic resources, indigestion and dyspepsia can lead to depression. In modern medicine, though many somatic diseases have been named as possible causes of depression, the effect of gastrointestinal disorders on depression is still an enigma. Therefore, the focus of this study is to explore the available scientific literature of modern medicine in order to find the footprint of effect of indigestion on depression. In this study, related articles were retrieved from PubMed, Ovid, Proquest and Magiran databases by using the Medical Subject Heading keywords "depression," "psychology," "dyspepsia" and "gastrointestinal diseases." In the next step, studies, which are exactly confirm the Islamic viewpoint, were selected from the retrieved articles. Only one prospective study in 2012 has stated that people with functional gastrointestinal disorders and without elevated levels of anxiety and depression at baseline had significantly higher levels of anxiety and depression at 12-year follow-up. Based on Islamic viewpoint, indigestion can lead to depression, but this aspect approved by only one 12-year prospective population-based study in our review. It seems that it is necessary to conduct complementary studies investigating this hypothesis.
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PMID:Depression and Dyspepsia: An Implication of Islamic Resources. 2635 48

This study examines experiences of individual patients and psychiatrists in the Henry Phipps Psychiatric Clinic at Johns Hopkins between 1913 and 1917. The dynamics of these patient-psychiatrist interactions elucidate the well-known conceptual shift in explanations of mental illness during the twentieth century, from somatic models rooted in the logic of "neurasthenia" and damaged nerves to psychodynamic models based on the notion of "subconscious conflict." A qualitative analysis of 336 cases categorized as functional disorders (a catchall term in this period for illnesses that could not be confirmed as organic diseases), shows that patients explained their symptoms and suffering in terms of bodily malfunctions, and, particularly, as a "breakdown" of their nervous apparatus. Psychiatrists at the Phipps Clinic, on the other hand, working under the direction of its prominent director, Adolf Meyer, did not focus their examinations and therapies on the body's nervous system, as patients expected. They theorized that the characteristic symptoms of functional disorders-chronic exhaustion, indigestion, headaches and pain, as well as strange obsessive and compulsive behaviors-resulted from a distinct pathological mechanism: a subconscious conflict between powerful primal and social impulses. Phipps patients were often perplexed when told their physical symptoms were byproducts of an inner psychological struggle; some rejected the notion, while others integrated it with older explanations to reconceptualize their experiences of illness. The new concept also had the potential to alter psychiatrists' perceptions of disorders commonly diagnosed as hysteria, neurasthenia, or psychoneuroses. The Phipps records contain examples of Meyer and his staff transcending the frustration experienced by many doctors who had observed troubling but common behaviors in such cases: morbid introspection, hypochondria, emotionalism, pity-seeking, or malingering. Subconscious conflict recast these behaviors as products of "self-deception," which both absolved the sufferer and established an objective clinical marker by which a trained specialist could recognize functional disorder. Using individual case studies to elucidate the disjunction between patients' and psychiatrists' perspectives on what all agreed were debilitating illnesses, this analysis helps to illuminate the origins of a radical transformation in psychiatric knowledge and popular culture in the twentieth century-from somatic to psychodynamic explanations of mental illness.
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PMID:"MY RESISTING GETTING WELL": NEURASTHENIA AND SUBCONSCIOUS CONFLICT IN PATIENT-PSYCHIATRIST INTERACTIONS IN PREWAR AMERICA. 2691 53

Methods to characterize and quantify severity of chronic nausea and vomiting and to elucidate their underlying mechanisms have received significant attention for both adult and pediatric patients. Validated dyspepsia symptom surveys include measures of nausea and vomiting intensity in relation to other upper gut symptoms. Visual analog scales quantify nausea intensity in real-time in physiologic studies and have been employed as enrollment criteria in clinical trial settings. A new nausea and vomiting survey has been administered to gastroparesis patients to provide insight into timing, triggers, and autonomic and psychological correlates of these symptoms. Several gastric sensorimotor and extragastric abnormalities are proposed to contribute to nausea and vomiting pathogenesis, but their relations to symptom severity are either limited or uninvestigated. Gastric emptying delays are prevalent in patients with chronic nausea and vomiting, as are blunting of fundic accommodation, aberrant gastric slow wave rhythms, and heightened perception of noxious and physiologic luminal stimulation. Potential extragastric correlates of nausea and vomiting include transit delays distal to the stomach, autonomic abnormalities, altered central nervous system activation, metabolic dysregulation, and psychological dysfunction. One goal of novel survey development will be to relate these physiologic correlates to specific symptom presentations to gain insight into mechanisms of nausea in different clinical conditions. Pediatric patients represent special challenges because of the different disorders that cause nausea and vomiting in children and differences in understanding disease manifestations, the ability to communicate symptom intensity and characteristics, and immature coping mechanisms compared to adults.
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PMID:Methodologic considerations for studies of chronic nausea and vomiting in adults and children. 2753 28

Hospital admission and mortality statistics suggested that peptic ulcer reached a peak prevalence in the mid-1950s. During the Second World War, against this background of serious and common pathology, an epidemic of dyspepsia afflicted both service personnel and civilians alike. In the absence of reliable diagnostic techniques, physicians struggled to distinguish between life-threatening illness and mild, temporary disorders. This article explores the context in which non-ulcer stomach conditions flourished. At a time when fear was considered defeatist and overt psychological disorder attracted stigma, both soldiers and civilians exposed to frightening events may have unconsciously translated their distress into gastrointestinal disorders. While the nature of army food was initially identified as the cause of duodenal ulcer in servicemen, the pre-war idea that conscientious and anxious individuals were at high risk gathered support and fed into post-war beliefs that this was a stress-related illness. Diet continued to be employed as a means of management at a time when the nation was preoccupied by food because of the constraints imposed by rationing. The peptic ulcer phenomenon set much of the medical agenda for the war years and conflicted with the commonly held view that the British people had never been healthier.
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PMID:'The gut war': Functional somatic disorders in the UK during the Second World War. 2791 25


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