Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0013395 (dyspepsia)
 4,879 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In total 199 oesophago-gastro-duodenoscopies (OGD) were performed in 71 female and 71 male paediatric patients (three months-15 years, median 8 years 2 months). The endoscopy was performed in general anaesthesia in children less than five years old, and in an intravenous sedation in older patients. The indications for OGD were: recurrent abdominal pain and concomitant positive antibodies against Helicobacter pylori as a part of a scientific project, upper dyspepsia, upper gastrointestinal bleeding, failure to thrive, coeliac disease, suspicion of chronic inflammatory bowel disease and a percutaneous gastrostomy. Seventy-two OGD were carried out in general anaesthesia, 86 in intravenous sedation with midazolam and pethidine and 41 in intravenous midazolam sedation. Complications related to the sedation or to the endoscopy were not observed. Amnesia was reported in 94/95 children who were sedated intravenously with midazolam and pethidine or midazolam alone. Six endoscopies could not be carried out in intravenous sedation because of agitation. In the primary OGD endoscopy revealed a normal mucosa in 121/142 (85%), oesophagitis in four (3%), nodular mucosa in six (4%), gastritis in four (3%) and a duodenal ulcer in one (0.7%). Histology disclosed active or inactive chronic gastritis at the primary endoscopy in 35/69 (51%) of the children with recurrent abdominal pain and antibodies against H. pylori. In children with failure to thrive an avillous duodenal mucosa was seen in 3/32 (9%). A comparison between histological and stereomicroscopical evaluation of the duodenal biopsies revealed agreement in 41/47 (87%). We conclude that OGD is a safe and tolerable procedure in paediatric patients, in whom possible morphological changes are suspected. The indications for an OGD need further evaluation.
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PMID:[Esophago-gastro-duodenoscopy of pediatric patients]. 919 Jul 31

The rapid rise in the number of the independent elderly persons in the community has become a world-wide phenomenon. Recently, more attention has been devoted to community based programs for the elderly. One type of these programs offering multiple services is the elderly clubs. These clubs may provide health and physical care beside social interaction and peer group support for the independent elderly in the community. In Alexandria, elderly health and social care provided are not coping with the increasing numbers of the aged population and consequently with their needs and problems. So the aim of this study was to describe the health profile of the consumers of the elderly clubs in Alexandria and to determine the preferred activities needed by the consumers of the elderly clubs in Alexandria. To fulfil this aim, a sample of 163 elderly representing the consumers from all (five) elderly clubs in Alexandria were interviewed. The results revealed that almost one third (30.67%) of the elderly consumers had no health complaints, 35.58% had only one health complaint and 33.74% had more than one complaint. The most health complaints stated by the consumers were cardiovascular diseases/hypertension followed by diabetes mellitus then rheumatic diseases/arthritis. The results also revealed that all the elderly consumers had one or more minor signs and symptoms during the last six months of the interview. These signs and symptoms varied from amnesia, low concentration, constipation, dizziness and dyspepsia. The majority of the elderly consumers preferred the recreational trips and attending religious seminars/reading Quraan. Walking and checking on blood pressure were the most preferred activities mentioned by nearly half the consumers. The results of this study can be considered as a base line data to help policy makers in taking decisions during planning and providing the needed services to the elderly.
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PMID:Do elderly clubs in Alexandria meet the needs of their consumers? 1721 65

Introduction: "Medically Unexplained Physical Symptoms" (MUPS) defines a subgroup of patients presenting physical symptoms of unclear origin. The study aims to profile clinical and socio-demographic characteristics of patients with MUPS. Materials and Methods: This 9-years observational retrospective study assesses all patients admitted between 2008 and 2016 in the divisions of neurology and gastroenterology. Socio-demographic and clinical variables were evaluated: gender, age, diagnosis or diagnostic hypothesis, presence of psychiatric comorbidities, psychiatric evaluation, pharmacological treatment, number of admissions/visits. Results: Among 2,479 neurological patients 10.1% presented MUPS. Patients were more frequently women (63.5%), with a mean age of about 50 years. Reported symptoms were headache (22.6%), seizures (8.7%), vertigo (5.9%), fibromyalgia (5.5%), paresthesia (5.1%), visual disturbances (5.1%), amnesia (3.9%). The diagnosis was somatoform disorder in 6.3% of cases, conversion disorder in 2.7%, and somatic symptom disorder in 1.5% only. 2,560 outpatients were evaluated in gastroenterology division. 9.6% (n = 248) of patients had MUPS; 62.1% of them were women. The most affected age group ranged between 15 and 45 years. The most frequent diagnoses were functional abdominal pain (50%), dysmotility-like dyspepsia (26.6%), irritable bowel syndrome (10.4%), meteorism of unknown cause (2.4%), hiccup (1.6%), burning mouth syndrome (1.2%). No patients received a diagnosis of somatic symptom disorder. Discussion: Patients with MUPS are more often women, of middle age, with self-referred specific symptomatology. While neurological patients received a diagnostic-therapeutic approach in line with the literature, gastroenterological patients mainly received antipsychotics. A more comprehensive assessment and a development of psychoeducational interventions are needed to improve patients' quality and quantity of life.
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PMID:Medically Unexplained Physical Symptoms in Hospitalized Patients: A 9-Year Retrospective Observational Study. 3053 14