Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0013395 (dyspepsia)
 4,879 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

By "Rumen acidosis" until recently only the acute indigestion with intoxication caused by excessive production of lactic acid was understood. Meanwhile, however, it has become evident that further pathologic changes can take place in the acid-base status of the rumen contents which may also be referred to as "Rumen acidosis". Basing on new literature and own experiences the paper gives a review of that "Rumen acidosis complex": Fundamentals of the regulation of pH in the rumen; chronic latent rumen acidosis (hyper- and parakeratosis, chronic hyperplastic rumenitis, rumenitis-liver abscess complex, hyperlipodeposition, low milk fat syndrome, atypical ketosis, chronic laminitis, cerebrocortical necrosis, acid-base metabolism); acute lactic acidosis (etiology, pathogenesis, therapy, prophylaxis).
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PMID:[Ruminal acidosis complex--new observations and experiences (2). A review]. 287 33

By "Rumen acidosis" until recently only the acute indigestion with intoxication caused by excessive production of lactic acid was understood. Meanwhile, however, it has become evident that further pathologic changes can take place in the acid-base status of the rumen contents which may also be referred to as "Rumen acidosis". Basing on new literature and own experiences the paper gives a review of that "Rumen acidosis complex": Fundamentals of the regulation of pH in the rumen; chronic latent rumen acidosis (hyper-and parakeratosis, chronic hyperplastic rumenitis, rumenitis-liver abscess complex, hyperlipodeposition, low milk fat syndrome, atypical ketosis, chronic laminitis, cerebrocortical necrosis, acid-base metabolism); acute lactic acidosis (etiology, pathogenesis, therapy, prophylaxis).
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PMID:[The rumen acidosis complex--recent knowledge and experiences (1). A review]. 383 44

Microbial and fermentation changes in the ingesta of the large intestine and their influence on the pathogenesis of acute lactic acidosis were studied in 4 cows fitted with permanent cannulas in the ileum and cecum. Feed mixture containing 65% of maize was infused into the cecum for several days in amounts of 2 and 4 kg per day. The daily amount was divided in 8 equal portions and given with 3 l of warm physiologic saline solution. During the period of ad libitum feeding of hay, the pH values in cecal digesta were 7.4 to 7.6 and the amount of total volatile fatty acids 40-60 mmol/kg with high molar percentage (87-90 mol%) of acetic acid. As to lactic acid only the L(+) lactic isomer was found in a concentration of about 0.4 mmol/kg. Infusion of low amounts of starch induced mild lactic acid fermentation in the cecum associated with a pronounced increase in the concentration of L(+) and D (-) lactic acid to peak levels of 80 +/- 10 mmol/kg and 7 +/- 1 mmol/kg, respectively. Lactic acid fermentation ceased within 2 to 3 days indicating that the gut microflora had adapted to the starch infusion. Slight decreases of blood pH and bicarbonates in blood as well as a moderate increase of netto acid-base excretion in urine indicated mild changes of acid-base balance, but clinically no pathological symptoms were observed. Higher amounts of infused starch caused pronounced lactic acid production in the large intestine which persisted throughout the experiment. Peak L(+) and D(-) lactic acid concentration in cecal digesta reached on the average 137 +/- 16 mmol/kg and 45 +/- 7 mmol/kg respectively. Significant decreases of blood pH values from 7.41 +/- 0.02 to 7.18 +/- 0.08 (P < 0.001), actual bicarbonate from 28.2 +/- 3.2 to 11.0 +/- 2.6 mmol/l (P < 0.001) and base excess from 3.9 +/- 3.6 to -15.2 +/- 3.8 mmol/l (P < 0.001) were observed. D (-) lactic acid concentration in blood increased to 3.2 +/- 0.4 mmol/l, but L(+) lactic acid values remained unchanged under 1 mmol/l. Clear clinical symptoms of indigestion and intoxication characterized by severe inappetence, ruminal stasis and general weakness were also observed. Typical clinical symptoms of disease as well as blood and urine changes in acid-base balance indicated that lactic acid fermentation in the large intestine contributes considerably to the pathogenesis of acute ruminant lactic acidosis.
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PMID:[Impact of lactic acid fermentation in the large intestine on acute lactic acidosis in cattle]. 1147 93

Biguanides can function as oral antihyperglycemic drugs. They were used for diabetes mellitus or prediabetes treatment over the last nine decades, but they lost their popularity in 1970s because of phenformin and regained with metformin. For metformin, the most common side effects are diarrhea and dyspepsia, occurring in up to 30% of patients. The most important and serious side effect is lactic acidosis. Phenformin was removed from the markets before 1970, because it caused lactic acidosis in 40-65 patients in 100,000 patient-years. Metformin causes lactate accumulation only in patients who have hepatic failure, renal failure or in patients who attempt suicide with high dosage of drugs. In this report, we present five patients who used high doses of metformin for suicide attempt.
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PMID:Suicide commitment with metformin: our experience with five cases. 2374 66