Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0013362 (dysarthria)
 3,768 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Solitary fibrous tumours (SFT) of the central nervous system are rare. Such lesions are mesenchymal neoplasms that resemble meningioma. To date, 73 cases of SFT have been reported in the literature, but there is no reported case of an SFT that extends into both the supratentorial and infratentorial spaces. A 76-year-old man presented with headache, dysarthria and ataxia of 2 months' duration. MRI revealed a right cerebellar tumour, extending superiorly to the occipital lobe. During surgery, a huge, solid and well-capsulated tumour was observed. The tentorium cerebelli was also damaged by the tumour. Histological and immunohistochemical studies confirmed the diagnosis of SFT. This is the first reported case of SFT located in both the infratentorial and supratentorial spaces. SFT are spindle cell neoplasms with a characteristic immunohistochemical profile of CD34, vimentin and bcl-2 positivity.
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PMID:Solitary fibrous tumour extending both supratentorially and infratentorially. 1840 98