Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0013362 (
dysarthria
)
3,768
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We report five of 38 patients with stiff person syndrome (SPS), who also had cerebellar disease, gait ataxia,
dysarthria
, and oculomotor dysfunction (SPS-
Cer
). Cerebellar manifestations either preceded SPS or occurred concurrently. Brain MRI was normal. The intrathecal production of glutamic acid decarboxylase antibodies was elevated. Gamma-aminobutyric acid-enhancing drugs and immunotherapies improved only the stiffness. SPS-
Cer
is a distinct subset of SPS causing a more severe and complex clinical phenotype.
...
PMID:Stiff person syndrome with cerebellar disease and high-titer anti-GAD antibodies. 1740 5
