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Query: UMLS:C0013362 (dysarthria)
 3,768 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Acoustic data are provided in order to facilitate evaluation of the speech of adult patients with prosody disorders such as dysarthria. Forty French-speaking subjects between 45 and 75 years of age, with neither neurological disease nor a communication disorder, were grouped on the basis of sex and age. Subjects were required to produce four series of 20 matched interrogative and declarative sentences. Their productions were recorded and analyzed with an IBM Speech Viewer. Measures of fundamental frequency, of variation in fundamental frequency, of rate over the entire sentence, as well as a measure of intonation (defined as the difference in fundamental frequency between the last syllable of matched declarative and interrogative sentences) are reported in tables for clinical use. These data provide information for the evaluation of the prosody of French-speaking persons.
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PMID:[Values of certain prosodic parameters obtain with French-speaking probands without communication problems]. 772 80

Ten dysarthric speakers of various etiologies, type, and severity were compared to age-matched and gender-matched nondysarthric speakers on 40 short sentences. These sentences were presented in both declarative and interrogative versions. Measures of (1) mean intonation difference (average difference in fundamental frequency between the last syllables of interrogative and declarative sentences) and (2) speech rate were obtained using the IBM Speech Viewer system. Analyses of variance were performed on the resulting measures with subject group, sentence type, and sentence sets as independent variables. Results indicate that (1) intonation values are significantly reduced in the dysarthric group as compared to those for the nondysarthric group; (2) rate varies as a function of subject group, sentence type, and sentence set. Moreover, intonation varies with severity of dysarthria, but not speech rate. These findings concur with the notion that dysarthria is a deficit in performance rather than in competence. The results are also discussed in reference to "breath-group" theory for intonation (Lieberman, 1967).
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PMID:Intonation and speech rate in dysarthric speech. 800 3

The purpose of this study was to identify and compare the recognition of dysarthric speech by a computerized voice recognition (VR) system and non-hearing-impaired adult listeners. Intelligibility "functions" were obtained for six dysarthric speakers who varied in severity and six age- and gender-matched controls. Speakers produced 70-item word lists over 5 sessions. VR using the IBM VoiceType and perceptual judgment scores were obtained and functions plotted by session. Data indicate that computerized recognition of both dysarthric and nonimpaired speech was characterized by initially steep increases in correct recognition with more gradual increases noted during the second through fifth sessions. Perceptual recognition by non-hearing-impaired adults indicates generally stable intelligibility scores over time. Severity of dysarthria did appear to influence recognition of target stimuli. Implications of these data to the application of computerized VR technology are presented.
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PMID:Dysarthric speech: a comparison of computerized speech recognition and listener intelligibility. 923 24

We reported a 71-year-old man with inclusion body myositis with clinically overt dysarthria. He had been suffering from gradual progression of weakness in the hand muscles and lower extremities as well as dysarthria three years before admission. His neurological examination revealed muscle atrophy and weakness in the tongue, the forearm flexors, and the vastus medialis muscles. He had dysarthria to a moderate degree, while he denied any dysphasia. A biopsy from vastus lateralis muscle showed variation in fiber size, infiltration of mononucleated cells, and numerous fibers with rimmed vacuoles, leading to the diagnosis of definite inclusion body myositis. The EMG findings of the tongue demonstrated low amplitude motor unit potentials during voluntary contraction, abundant fibrillation potentials at rest, and preserved interference pattern at maximal contraction, implying myogenic changes. We surmised the dysarthria seen in this patient, an atypical clinical feature in IBM, presumably caused by muscle involvement in the tongue muscle. Dysphasia is common symptom in IBM patient and has been much reported previously. But dysarthria in IBM patient has not been aware, for this reason this report should be the rare case.
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PMID:[A rare complication of dysarthria in a patient with inclusion body myositis: a case report]. 2106 47

Mutations in valosin-containing protein (VCP) are associated with a syndromic constellation of inclusion body myositis, Paget's disease of bone and frontotemporal dementia. Here we describe the case reports of two patients with a novel variation (p.I27V) in the VCP gene that was not identified in a healthy control population. One patient presented with a frontotemporal dementia syndrome associated with raised serum alkaline phosphatase and a family history of progressive muscle disease and behavioural decline, while the second patient presented with isolated progressive dysarthria. Together these cases suggest a potential for the same VCP mutation to produce distinct patterns of brain damage, underlining the clinical heterogeneity of VCP-associated disease.
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PMID:A novel exon 2 I27V VCP variant is associated with dissimilar clinical syndromes. 2138 14

We report the case of a 75-year-old woman who was found to have hepatitis C virus (HCV) infection in 1987. Before treatment in 2016, she was found to have mixed cryoglobulinemia (MC). Direct-acting antiviral (DAA) treatment produced a sustained virological response 12 (SVR12). She noticed gradual muscle weakness in 2015 and the gradual development of dysarthria and dysphagia in 2017. We performed a muscle biopsy that showed inclusion body myositis (IBM). To the best of our knowledge, this is first case of a patient with HCV infection, MC, and IBM, in which MC and IBM did not improve after an SVR12 was obtained by DAA treatment.
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PMID:A Patient with HCV Infection and a Sustained Virological Response to Direct-acting Antiviral Treatment Who Developed Inclusion Body Myositis. 2960 61