Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0013362 (dysarthria)
 3,768 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Diadochokinetic rate has traditionally been used for assessment, diagnosis and therapy in patients who suffered from oral cancer resection, glossectomy, oral myofunctional disease, dysphagia, dysarthria, functional articulation disorders or apraxia of speech. This is because diadochokinetic rate shows the documented structural and physiological changes in the central nervous system and the peripheral components of oral and speech production mechanism. Diadochokinetic rates were obtained from seventy-six normal subjects by counting the repetition of oral function (/a:-u:/; /u:-i:/; and /i:-a:/), tongue function (tongue movement from side to side of lip corner and lan lan lan lan la), and lip-tongue function (/p-t-k/ and /ph-th-kh/) in 15 seconds. The Count-by-Time test was used for data collection. The finding showed average diadochokinetic rates (syllables or times per 15 seconds) were 33.6, 33.16, 30.58; 24.21, 15.10, 26.50 and 26.30 for /a:-u:/, /u:-i:/, /i:-a:/, tongue movement from side to side of lip corner, lan lan lan lan la, /p-t-k/, and /ph-th-kh/. Most of the correlation analysis showed a high positive relationship. The results of this study are guidelines of normal diadochokinetic rates. In addition, they can indicate the severity of diseases and evaluation of treatment.
 ...
PMID:Oral diadochokinetic rate in adults. 980 70

The present study aimed to verify the importance of postoperative articulatory rehabilitation in patients with oral cancer and to clarify the neurological changes underlying articulatory functional recovery. A longitudinal assessment of oral function and accompanying brain activity was performed using non-invasive functional magnetic resonance imaging (fMRI). We assessed 13 patients with cancers of the tongue and oral floor before and after ablative surgery. Articulatory function was assessed preoperatively and postoperatively using a conversation intelligibility test and the Assessment of Motor Speech for Dysarthria test. Patients also performed a verbal task during fMRI scans. The assessments were then repeated after the patients had undergone 4-6 months of articulatory rehabilitation therapy. Compared to pretreatment levels, articulatory rehabilitation resulted in a significant increase in activation in the supplementary motor cortex, thalamus, and cingulate cortex. The present study offers a quantitative assessment of the effects of speech rehabilitation by investigating changes in brain activation sites.
...
PMID:Effect of articulatory rehabilitation after oral cancer surgery on higher brain activation. 2467 50