Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0013362 (dysarthria)
 3,768 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Familial visceral neuropathy (FVN) is a heterogeneous group of disorders due to abnormalities of the myenteric plexus. FVN with neuronal intranuclear inclusions is one particular form of FVN with a variable phenotype that includes achalasia, gastro-esophageal reflux, intestinal dysmotility and pseudo-obstruction, dysarthria, peripheral neuropathy and pupillary defects, and the presence of intranuclear inclusions within the neurons of the enteric nervous system. We present a four-generation family in which 10 individuals (7 of whom have been examined) are affected with FVN. The family was previously reported as familial esophageal achalasia, an autosomal recessive condition (MIM200400). At that time, several individuals in a single sibship were affected and there were no manifestations in either parent. Since that report, two individuals have had affected children and the mother has developed symptoms and has abnormalities on electromyography, thus enabling us to reclassify the family. This family provides further evidence of autosomal dominant inheritance, with marked variation in expression.
 ...
PMID:Familial visceral neuropathy: a defined entity? 1608 14

A 63-year-old woman presented with 24 hours of dysarthria, confusion, and appendicular ataxia preceded by watery diarrhea, without fever, nausea, vomiting, meningeal signs, recent travel, or antibiotic use. She had type II diabetes and gastroesophageal reflux disease (on proton pump inhibitor). She had consumed inadequately cooked beef stew left at room temperature for 24 hours. Blood cultures were positive for Salmonella typhimurium. CSF showed 15 nucleated cells, 72% monocytoid; remainder of CSF was normal. MRI was consistent with cerebellitis (figure). At 3 months, after 3 weeks of IV ceftriaxone, she remained dysarthric with bilateral dysmetria.
 ...
PMID:Teaching NeuroImages: acute cerebellitis caused by Salmonella typhimurium. 2347 71

Temporomandibular joint dislocation (TMJ) is sometimes found in post-stroke patients, and most cases occurs involuntarily. This report describes a rare case of repeated, voluntary, TMJ in a 73-year-old woman with dysphagia and dysarthria. The cause of dislocation was suspected to be voluntary excessive mouth opening associated with gastroesophageal reflux-related vomiting and the desire to eject oral deposits resulting from hypoglossal and facial nerve paralyses. After an oral hygiene intervention, the frequency of TMJ dislocation decreased and finally disappeared. Thorough oral hygiene seemed to contribute to protection against TMJ dislocation. (J Oral Sci 58, 133-136, 2016).
...
PMID:Temporomandibular joint dislocation in a post-stroke patient with dysphagia caused by gastroesophageal reflux-related vomiting. 2702 50