Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0013080 (Down syndrome)
 14,180 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
chromosome 21 0.063
DYRK1A 0.005
GATA1 0.002
DSCR1 0.002
pregnancy-associated plasma protein A 0.001
RCAN1 0.001
amyloid precursor protein 0.001
alpha-fetoprotein 0.001
TPRD 0.001
DSCAM 0.001
MNB 0.001
BSAC 0.000
ETS2 0.000
TTC3 0.000
CRLF2 0.000
DSCR 0.000
Down syndrome candidate region 1 0.000
C21orf5 0.000
PLAC4 0.000
P2RY8 0.000
CRELD1 0.000
SH3BGR 0.000
chorionic gonadotropin 0.000
phosphorylation regulated 0.000
DSCR4 0.000
KIR4.2 0.000
mnb 0.000
GARS-AIRS-GART 0.000
DSCR8 0.000
WDR9 0.000
CAF1A 0.000
PFKL 0.000
ZAKI-4 0.000
transcription factor GATA-1 0.000
DSCR3 0.000
APP 0.000
COL6A1 0.000
PDXK 0.000
KIAA0136 0.000
GLIS2 0.000
AFP 0.000
WRB 0.000
amyloid beta 0.000
TMEM131 0.000
TMEM50B 0.000
KIAA0179 0.000
Down syndrome cell adhesion molecule 0.000
ZNF295 0.000
methionine synthase reductase 0.000
RUNX1 0.000
A4 protein 0.000
CBFA2T3 0.000
PCP4 0.000
PKNOX1 0.000
tetratricopeptide repeat domain 3 0.000
TMEM1 0.000
MTRR 0.000
ZNF298 0.000
C21orf24 0.000
ZBTB21 0.000
C21orf7 0.000
C21orf69 0.000
C21orf4 0.000
transmembrane protein 50B 0.000
PRED54 0.000
PWP2H 0.000
PRED34 0.000
OTT-MAL 0.000
C21orf51 0.000
LAMNB1 0.000
C21orf66 0.000
DSCR10 0.000
C21orf42 0.000
DCRB 0.000
S100B 0.000
DSCR1L2 0.000
Pbx regulating protein 1 0.000
KCNJ6 0.000
DYRK4 0.000
DYRK1B 0.000
more...
Disease
Down syndrome 1.000
trisomy 0.011
trisomy 13 0.005
Edwards 0.003
mental retardation 0.003
mental retardation 0.003
Alzheimer's disease 0.002
TMD 0.002
megakaryocytic leukemia 0.001
septal defect 0.001
triploidy 0.001
Turner syndrome 0.001
fragile X syndrome 0.001
dementia 0.001
monosomy 21 0.001
Williams syndrome 0.001
autism 0.000
developmental disabilities 0.000
Klinefelter's syndrome 0.000
leukemia 0.000
DSCR 0.000
Atlantoaxial instability 0.000
ventricular septal defect 0.000
heart disease 0.000
mental handicap 0.000
genetic disorder 0.000
hypogonadotropic hypogonadism 0.000
abortion 0.000
acute myeloid leukemia 0.000
moyamoya 0.000
cerebral palsy 0.000
HCHWA 0.000
pediatric acute megakaryocytic leukemia 0.000
hygroma 0.000
Pick's disease 0.000
chromosome disorder 0.000
hypothyroidism 0.000
premature aging 0.000
acute lymphoblastic leukemia 0.000
trisomy 8 0.000
Rett syndrome 0.000
myeloproliferative disorders 0.000
Common atrioventricular canal 0.000
pediatric AML 0.000
atrial septal defect 0.000
leukemoid reaction 0.000
untreated childhood AML 0.000
keratoconus; congenital 0.000
Myeloproliferative Disease 0.000
adult acute megakaryoblastic leukemia (M7) 0.000
Fetal chromosomal abnormality 0.000
HPE1 0.000
trisomy 22 0.000
Congenital heart disease 0.000
severe mental retardation 0.000
Autism 0.000
trisomy 15 0.000
Congenital Malformation 0.000
myeloid leukemia 0.000
cognitive impairment 0.000
developmental delay 0.000
DFNB10 0.000
cri-du-chat syndrome 0.000
trisomy 14 0.000
tetrasomy 21q 0.000
Optic disc hypoplasia 0.000
acute leukemia 0.000
leukemogenesis 0.000
trisomy 2 0.000
XYY syndrome 0.000
brachycephaly 0.000
Basal ganglia calcification 0.000
Congenital knee dislocation 0.000
Fixation nystagmus 0.000
Congenital duodenal stenosis 0.000
familial Alzheimer disease 0.000
trisomy 9 0.000
pulmonary hypertension 0.000
congenital hypothyroidism 0.000
partial monosomy 21q 0.000
more...
Symptom
hypotonia 0.000
Cri du chat 0.000
Flaccidity 0.000
hepatosplenomegaly 0.000
Jitteriness 0.000
seizures 0.000
snoring 0.000
benign congenital hypotonia 0.000
Bilious vomiting 0.000
Eyelid retraction 0.000
Pyramidal signs 0.000
regurgitation 0.000
memory loss 0.000
myoclonus 0.000
cyanosis 0.000
vomiting 0.000
torticollis 0.000
drooling 0.000
stridor 0.000
weakness 0.000
Multimorbidity 0.000
respiratory distress 0.000
enuresis 0.000
ataxia 0.000
hepatomegaly 0.000
constipation 0.000
overweight 0.000
HSA 0.000
Behavioral symptoms 0.000
prominent nose 0.000
impaired motor coordination 0.000
delayed language development 0.000
anesthesia 0.000
Periodic breathing 0.000
gumma 0.000
Crawling 0.000
neck pain 0.000
catatonia 0.000
pallor 0.000
hematocolpos 0.000
abnormal gait 0.000
Acute urinary retention 0.000
Joint hypermobility 0.000
facial droop 0.000
chorea 0.000
bedwetting 0.000
Stepping 0.000
hyperemesis 0.000
hypertonia 0.000
chronic constipation 0.000
chromosome marker 0.000
DNA marker 0.000
tachypnea 0.000
cough 0.000
forgetfulness 0.000
clonus 0.000
pachyonychia 0.000
arm weakness 0.000
Neurologic symptoms 0.000
dysarthria 0.000
pain 0.000
thinning 0.000
Halo 0.000
tonic-clonic seizure 0.000
tonic seizure 0.000
labored breathing 0.000
diarrhea 0.000
lethargy 0.000
abdominal pain 0.000
clumsiness 0.000
physical appearance 0.000
ataxic gait 0.000
apathy 0.000
postnasal drip 0.000
body pain 0.000
splenomegaly 0.000
wheezing 0.000
CSR 0.000
dyspnea 0.000
fasciculation 0.000
more...
Drug
Dibotin 0.000
HCG 0.000
TEL 0.000
Palivizumab 0.000
Epigallocatechin 0.000
Thioguanine 0.000
ETS 0.000
anti-RSV 0.000
CMNX 0.000
Synthroid 0.000
Donepezil 0.000
MDS 0.000
Spectrum 0.000
Galanthamine 0.000
Ketalar 0.000
Frontal 0.000
Synthroid 0.000
Ketalar 0.000
Imuran 0.000
Aricept 0.000
Spectrum 0.000
Clofarabine 0.000
Dermatol 0.000
Pyridoxal phosphate 0.000
Posture 0.000
Piracetam 0.000
NLF 0.000
Mitomycin-C 0.000
Phosphoramidon 0.000
FAD 0.000
Glucantime 0.000
AraC 0.000
Cobalamin 0.000
Urokinase 0.000
Mutagen 0.000
CPO 0.000
vitamin E 0.000
Sodium valproate 0.000
Cardiovasc 0.000
CSF 0.000
Vitamin E 0.000
Leaf 0.000
Cilostazol 0.000
Botox 0.000
Bosentan 0.000
Bosentan 0.000
LCM 0.000
LCM 0.000
Prednisone 0.000
Maltose 0.000
ROC 0.000
Growth hormone 0.000
Etoposide 0.000
THF 0.000
Glutamic acid 0.000
Antithrombin III 0.000
ENT 0.000
Vicryl 0.000
ascorbate 0.000
MRC 0.000
Misoprostol 0.000
Vitamin B12 0.000
ABC 0.000
Vitamin B 0.000
CED 0.000
Viagra 0.000
NBT 0.000
CPM 0.000
IL-2 0.000
IL-1ra 0.000
Digitalis 0.000
VCR 0.000
ROS 0.000
Fraction 0.000
Kainic acid 0.000
Depo-Provera 0.000
Portal 0.000
GEO 0.000
Tocopherol 0.000
DM1 0.000
more...
Enzyme
pregnancy-associated plasma protein-A 0.000
methionine synthase reductase 0.000
methylenetetrahydrofolate reductase 0.000
methylenetetrahydrofolate reductase 0.000
superoxide dismutase 0.000
cystathionine beta-synthase 0.000
calcineurin 0.000
beta-secretase 0.000
AIR synthetase 0.000
choline acetyltransferase 0.000
STR 0.000
methionine synthase 0.000
coagulation factor XIa 0.000
methionine synthase 0.000
GAR 0.000
nardilysin 0.000
CLK1 0.000
glutathione peroxidase 0.000
neurosin 0.000
acetylcholinesterase 0.000
inositol polyphosphate 4-phosphatase 0.000
carbonyl reductase 0.000
CD13 0.000
methylenetetrahydrofolate dehydrogenase 0.000
6-pyruvoyltetrahydropterin synthase 0.000
dihydroxyacetone-phosphate acyltransferase 0.000
glutamine transaminase K 0.000
PdxH 0.000
pyridoxal kinase 0.000
protein kinase 0.000
3-mercaptopyruvate sulfurtransferase 0.000
PRPP synthetase 0.000
protein methylase II 0.000
methylenetetrahydrofolate dehydrogenase 0.000
phosphofructokinase 0.000
cholinesterase 0.000
dihydroxyacetone phosphate acyltransferase 0.000
cystathionine gamma-lyase 0.000
enolase 0.000
CD10 0.000
6-phosphogluconolactonase 0.000
focal adhesion kinase 0.000
glutaminyl cyclase 0.000
catalase 0.000
peroxidase 0.000
insulin-degrading enzyme 0.000
GSK 0.000
GTI 0.000
superoxide reductase 0.000
dihydropyrimidinase 0.000
ERK 0.000
7-dehydrocholesterol reductase 0.000
inositol phosphatase 0.000
glycinamide ribonucleotide transformylase 0.000
betaine-homocysteine methyltransferase 0.000
type 1 protein phosphatase 0.000
homocysteine methyltransferase 0.000
3'-phosphatase 0.000
adenine phosphoribosyltransferase 0.000
kynurenine aminotransferase 0.000
TSR 0.000
CEP 0.000
adenylosuccinate lyase 0.000
neutrophil collagenase 0.000
glutathione reductase 0.000
phosphatidylinositol-4,5-bisphosphate 3-kinase 0.000
thimet oligopeptidase 0.000
N-acetylglucosaminyltransferase 0.000
phosphatidylethanolamine N-methyltransferase 0.000
transglutaminase 0.000
cytidine deaminase 0.000
complex I 0.000
HVS 0.000
pantothenate kinase 0.000
ceruloplasmin 0.000
alkaline phosphatase 0.000
CEP 0.000
biliverdin reductase 0.000
hypoxanthine-guanine phosphoribosyltransferase 0.000
dihydroorotase 0.000
more...
Compound
Retard 0.001
MMU 0.000
Butoctamide hydrogen succinate 0.000
DNA 0.000
NDS 0.000
Dec 0.000
Clin 0.000
CMK 0.000
homocysteine 0.000
TEL 0.000
Melezitose 0.000
Glycerophosphoethanolamine 0.000
Melezitose 0.000
Harmine 0.000
tyrosine 0.000
PAPP 0.000
Cystathionine 0.000
Cystathionine 0.000
oxygen 0.000
GABA 0.000
PAPP 0.000
GABA 0.000
Epigallocatechin 0.000
2-hydroxybutanoic acid 0.000
Cardiol 0.000
L-alpha-lysophosphatidylcholine 0.000
Xamoterol 0.000
CBS 0.000
TSH 0.000
2-hydroxybutanoic acid 0.000
Congo red 0.000
zinc 0.000
Phorbol-12,13-dibutyrate 0.000
Proflavine 0.000
Glycerophosphocholine 0.000
A 3 0.000
Thyroid 0.000
T13 0.000
1H-pyrrolo[2,3-b]pyridine 0.000
Memantine 0.000
calcium 0.000
Trenimon 0.000
His 0.000
Neuronal 0.000
PD 5 0.000
Ara-C 0.000
9Z,11E-octadecadienoic acid 0.000
1-amino-1,3-cyclopentanedicarboxylic acid 0.000
CHQ 0.000
PGA 0.000
DBM 0.000
silver 0.000
DBM 0.000
Potassium chloride 0.000
serine 0.000
Ural 0.000
Ara-C 0.000
CH3-THF 0.000
glutamate 0.000
Quinacrine 0.000
H2S 0.000
Cyclopamine 0.000
threonine 0.000
PAC 0.000
Dibucaine 0.000
MMD 0.000
A 1 0.000
6-Thioguanine 0.000
Quinacrine 0.000
LTD 0.000
folinic acid 0.000
AY9944 0.000
NMDA 0.000
Efron 0.000
Florid 0.000
selenium 0.000
superoxide radical 0.000
TFF 0.000
Isoform 0.000
DBC 0.000
more...