Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0013080 (Down syndrome)
 14,180 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
C21orf24 11.1
LAMNB1 11.1
PWP2H 11.1
PRED34 11.1
KIAA0136 11.1
C21orf42 11.1
C21orf66 11.1
C21orf51 11.1
C21orf69 11.1
DSCR10 11.1
DCRB 11.1
ZNF298 11.1
C21orf4 11.1
C21orf7 11.1
ZBTB21 11.1
PRED54 11.1
transmembrane protein 50B 11.1
CAF1A 11.1
DSCR8 11.1
WDR9 11.1
more...
Disease
untreated childhood AML 11.1
pediatric acute megakaryocytic leukemia 11.1
Down syndrome 11.1
adult acute megakaryoblastic leukemia (M7) 11.1
keratoconus; congenital 11.1
Myeloproliferative Disease 11.1
Fetal chromosomal abnormality 11.1
DSCR 10.4
tetrasomy 21q 10.1
Optic disc hypoplasia 10.1
Common atrioventricular canal 10.1
HPE1 9.8
Atlantoaxial instability 9.6
Congenital duodenal stenosis 9.5
Congenital knee dislocation 9.5
Fixation nystagmus 9.5
trisomy 13 9.4
monosomy 21 9.2
Meningococcal conjunctivitis 9.1
Neonatal leukaemia 9.1
more...
Symptom
Cri du chat 9.3
Flaccidity 8.5
Jitteriness 7.8
benign congenital hypotonia 7.0
Bilious vomiting 7.0
Eyelid retraction 6.9
Pyramidal signs 6.5
hypotonia 5.4
Multimorbidity 4.8
Behavioral symptoms 4.8
prominent nose 4.8
delayed language development 4.7
Periodic breathing 4.7
gumma 4.6
Crawling 4.6
impaired motor coordination 4.5
hepatosplenomegaly 4.3
drooling 4.3
snoring 4.2
hematocolpos 4.2
more...
Drug
Dibotin 9.1
Thioguanine 6.1
Palivizumab 6.0
CMNX 5.7
Synthroid 5.5
Epigallocatechin 5.3
TEL 5.2
Galanthamine 5.1
Ketalar 5.1
anti-RSV 4.9
Synthroid 4.7
HCG 4.6
Ketalar 4.6
Imuran 4.5
Aricept 4.4
Donepezil 4.3
Clofarabine 4.0
Pyridoxal phosphate 4.0
NLF 3.8
ETS 3.8
more...
Enzyme
pregnancy-associated plasma protein-A 8.5
methionine synthase reductase 7.6
AIR synthetase 7.3
coagulation factor XIa 6.9
nardilysin 6.2
neurosin 6.1
inositol polyphosphate 4-phosphatase 6.0
GAR 5.8
CLK1 5.6
6-pyruvoyltetrahydropterin synthase 5.6
dihydroxyacetone-phosphate acyltransferase 5.5
beta-secretase 5.5
glutamine transaminase K 5.5
cystathionine beta-synthase 5.5
PdxH 5.4
methylenetetrahydrofolate dehydrogenase 5.4
methylenetetrahydrofolate reductase 5.2
methylenetetrahydrofolate reductase 5.2
protein methylase II 5.2
methionine synthase 5.1
more...
Compound
Butoctamide hydrogen succinate 9.5
MMU 7.6
Melezitose 7.2
Glycerophosphoethanolamine 7.1
Melezitose 7.0
Retard 6.7
NDS 6.6
Harmine 6.2
PAPP 6.0
2-hydroxybutanoic acid 6.0
L-alpha-lysophosphatidylcholine 5.8
PAPP 5.8
2-hydroxybutanoic acid 5.6
CMK 5.5
Xamoterol 5.5
Phorbol-12,13-dibutyrate 5.4
Proflavine 5.4
Glycerophosphocholine 5.3
Cystathionine 5.3
Cystathionine 5.3
more...