Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0012872 (DNA marker)
 929 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In an experiment in which a human A gamma/beta-globin construct gene was introduced into the germ line of mice by microinjection, we obtained a transgenic male mouse carrying the construct gene on its Y-chromosome. This mouse carried 13 copies of a 8.9 kb construct gene as a head-to-tail tandem array, and showed a low level of transcription of the human A gamma- and beta-globin gene in the erythroid tissues. This transgenic mouse can be a useful tool in studies of embryology and developmental genetics because it carries a specific DNA marker on only its Y-chromosome.
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PMID:Transgenic mouse carrying a foreign gene on its Y-chromosome. 316 27