Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0012872 (DNA marker)
 929 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Cutaneous leishmaniasis in Venezuela has been associated with different Leishmania species and the visceral form is frequently related to L. chagasi. However, in this study we have characterized as L. colombiensis by molecular techniques some isolates of Leishmania from patients presenting either cutaneous or visceral leishmaniasis. Three different molecular markers (two DNA and one protein) were used to investigate the diversity among the L. colombiensis isolates. The analysis revealed the isolates to be similar although distinct from the reference strain of L. colombiensis. Slight variation among the isolates could not be correlated with any epidemiological features of the samples however the visceral isolates were observed to cluster on a phenetic tree derived from one DNA marker. The results confirm previous findings that L. colombiensis can cause both the cutaneous and visceral forms of the disease and that there exists at least two distinct etiological agents of American visceral leishmaniasis (AVL). The report also shows the necessity of careful differentiation of leishmanial isolates in any clinical or epidemiological study of human leishmaniasis.
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PMID:Genotypically distinct Leishmania colombiensis isolates from Venezuela cause both cutaneous and visceral leishmaniasis in humans. 1280 6

The sandfly Lutzomyia longipalpis s.l. is the main vector of American Visceral Leishmaniasis. L. longipalpis s.l. is a species complex but until recently the existence of cryptic sibling species among Brazilian populations was a controversial issue. A fragment of paralytic (para), a voltage dependent sodium channel gene associated with insecticide resistance and courtship song production in Drosophila, was isolated and used as a molecular marker to study the divergence between two sympatric siblings of the L. longipalpis complex from Sobral, Brazil. The results revealed para as the first single locus DNA marker presenting fixed differences between the two species in this locality. In addition, two low frequency amino-acid changes in an otherwise very conserved region of the channel were observed, raising the possibility that it might be associated with incipient resistance in this vector. To the best of our knowledge, the present study represents the first population genetics analysis of insecticide resistance genes in this important leishmaniasis vector.
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PMID:Genetic divergence between two sympatric species of the Lutzomyia longipalpis complex in the paralytic gene, a locus associated with insecticide resistance and lovesong production. 1905 28