Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0012833 (dizziness)
 9,689 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

There are a number of hereditary and non-hereditary central nervous system (CNS) disorders, which directly or indirectly affect the heart (brain-heart disorders). The most well-known of these CNS-disorders are epilepsy, stroke, subarachanoid bleeding, bacterial meningitis, and head injury. In addition, a number of hereditary and non-hereditary neurodegenerative disorders may impair cardiac functions. Affection of the heart may manifest as arrhythmias, cardiomyopathy, or autonomic dysfunction. Rarer cardiac complications of CNS disorders include heart failure, systolic or diastolic dysfunction, myocardial infarction, arterial hypertension, or pulmonary hypertension. Cardiomyopathy induced by hereditary CNS disease mainly include stress-induced myocardial dysfunction, known as Takotsubo syndrome (TTS). CNS disease triggering TTS includes epilepsy, ischemic stroke, subarachnoid bleeding, or PRES syndrome. Arrhythmias induced by hereditary CNS disease include supraventricular or ventricular arrhythmias leading to palpitations, dizziness, vertigo, fainting, syncope, (near) sudden cardiac death, or sudden unexplained death in epilepsy (SUDEP). Appropriate management of cardiac involvement in CNS-disorders is essential to improve outcome of affected patients.
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PMID:CNS-disease affecting the heart: brain-heart disorders. 2503 54

Posterior reversible encephalopathy is a rare clinical and radiological syndrome with a character type of change in the brain: vasogenic edema of the white matter, mainly in the occipital and parietal lobes, usually symmetric, which is a secondary manifestation of acute dysfunction of the posterior cerebrovascular system. The main pathophysiological mechanism of PRES is a violation of tone of cerebral vessels. Hyperactivity of sympathetic NS, oxidative stress, development of endothelial dysfunction, disorders of humoral homeostasis, particularly, interaction between a number of biochemical substances can trigger the last one. The main clinical manifestations are headache, disorders of consciousness (from somnolence to coma), visual disturbances (hemianopsia, scotoma, and cortical blindness), behavioral disorders, dizziness, nausea and vomiting, epileptic seizures. The article presents the description of clinical observation of the posterior reversible encephalopathy syndrome in a child verified by MRI-data.
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PMID:[POSTERIOR REVERSIBLE ENCEPHALOPATHY SYNDROME IN CHILDREN (CASE REPORT)]. 3214 47