Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0012833 (dizziness)
 9,689 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Thirty-eight patients with chronic vertigo and positional and/or spontaneous nystagmus finished a double-blind study to determine the efficacy of astemizole on nystagmus and its symptoms. Patients with Meniere's disease were excluded. The study took 13 weeks with a follow-up examination. Six to eight noncaloric electronystagmograms were recorded at determined intervals. Three doses of the drug, 5, 10, and 20 mg/d, and placebo were tested. A patient was considered a responder if the number of nystagmic beats occurring in eight head and body positions was reduced by 50% or more and the symptoms of vertigo were greatly reduced. Twenty-eight of the 38 patients were responders. Blood levels of astemizole were related to effectiveness. Patients did not respond to placebo. The onset of drug effect was slow. Astemizole appears to be useful and safe to try on the patient with chronic dizziness.
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PMID:Astemizole. Its use in the treatment of patients with chronic vertigo. 310 58

Astemizole, a new H1 antihistamine, was tested on 10 patients with chronic dizziness and either spontaneous or positional nystagmus. Patients with Meniere's disease were excluded from the study. The patients took 10 mg of astemizole per day for 30 days. Four ENGs were performed; one pre-drug, one after 2 weeks of drug, one after 4 weeks of drug and one post-drug ENG. Six of the 10 patients showed a clear decrease in spontaneous and/or positional nystagmus at the second and third ENG and a rebound of nystagmus when the drug was stopped. There was a positive relation between subjective symptoms and nystagmus. No side-effects were observed.
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PMID:Astemizole: its use in patients with chronic vertigo and eng signs--a pilot study of a new drug. 613 21