Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0012833 (dizziness)
 9,689 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Ten intensive care patients and five healthy volunteers each received a bolus injection of lidocaine HCl (100 mg, 2%) over an injection period of 5 s. After 0.5, 1, 2, 4, 8, 15 and 25 min arterial, central venous and peripheral venous blood samples were collected. In four of the volunteers, arterial and central venous samples were also taken about 10 s after the end of injection. The fluorescence polarization method by means of the Abbott-TDx system was used, and plasma concentrations of lidocaine were determined. The measurements showed that lidocaine levels in central venous plasma 10 s after the end of administration were higher than those in arterial plasma. By 30 s after administration the opposite situation had developed, so that arterial concentrations were higher than those in central venous plasma. This relation did not change throughout the study, though the two levels became closer, as is shown by the ratios (Table 3, Fig. 2). Concentrations in peripheral venous plasma increased more slowly but remained far below those in arterial and central venous plasma, at least for the first 8 min. After 15 min lidocaine levels were almost the same in all three samples. During the entire study there were no ECG changes, and neither heart rate nor blood pressure showed any significant deviation from the values obtained at the beginning. The volunteers had minor toxic manifestations, such as dizziness, tinnitus and a metallic taste in the mouth; one person had a sensation of pressure in his chest, which improved following oxygen administration.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:[The concentration of free lidocaine in arterial, central venous and peripheral vein plasma following intravenous injection]. 233 Apr 29

Anaemia in the immediate postnatal period can manifest itself physically in a number of ways. Amongst these are pallor, tiredness, dizziness, loss of appetite and oedema (Bewley 2004), all of which could be mistaken for commonly observed benign symptoms of the immediate postnatal period. However, left untreated, anaemia can severely impact on both the physical and emotional wellbeing of a woman and dramatically slow down her recovery (Bewley 2004). This altered state of health can also have a detrimental effect on a woman's ability to bond with her new child (Abbott et al 1997) and has been identified as a contributory factor in the initiation of postnatal depression (Corwin et al 2003). It is therefore imperative that, as midwives and student midwives, we take every opportunity to closely monitor the wellbeing of women in our care in order to facilitate their return to a normal haemoglobin level, promote infant bonding and reduce the risk of postnatal depression.
 ...
PMID:Postpartum anaemia. Are we vigilant enough? 2286 Mar 60

Implantation of the HeartMate 3 (HM3) left ventricular assist device (Abbott Laboratories, Lake Bluff, IL) continues to increase as the results of European and U.S. clinical trials become available. Although the large trials adequately capture the more common and expected outcomes, rare and unexpected clinical complications will continue to appear with higher volumes of implantation. This report describes a rare complication of severe refractory postural dizziness and syncope after successful implantation of an HM3 in a patient who ultimately required pump exchange to a HeartWare HVAD (HeartWare, Framingham, MA) for resolution of symptoms.
 ...
PMID:Severe Dizziness and Syncope After HeartMate 3 Implantation Requiring Pump Exchange. 3085 89