Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0012833 (dizziness)
 9,689 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Nephrogenic diabetes insipidus (NDI) is caused by the inability of renal collecting duct cells to respond to arginine vasopressin (AVP)/antidiuretic hormone (ADH). We present the case of a 7-year-old boy with a history of excretion of large amounts of dilute urine and polydipsia since infancy. The boy had several vomiting episodes with mild dehydration during the first 3 years of life. There was no evidence of headaches, dizziness or visual problems. He drinks between 2 and 3 L/day and has 24-hour diuresis of 2 liters, now. He has prepubertal appearance with appropriate weight [+0.85 standard deviation score (SDS)] and height (+0.15 SDS) for his age. His intelligence was also normal. The water deprivation test showed low urine osmolality after 8 hours of dehydration. After desmopressin administration, urine osmolality remained low. Serum osmolality was in the normal range for sex and age before and after desmopressin administration. This indicated a nephrogenic form of diabetes insipidus. Molecular analyses revealed a P286L [p.Pro(CCC)286Leu(CTC)] mutation in the AVPR2 gene, that was inherited from his mother. This patient is the first case with genetically confirmed X-linked inherited form of NDI in the Republic of Macedonia. Molecular analysis confirmed the clinical diagnosis and enabled genetic advice for this family.
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PMID:X-Linked Recessive form of Nephrogenic Diabetes Insipidus in a 7-Year-Old Boy. 2593 2

For several decades, low-frequency ultrasound (<100 kHz) has been widely used in industry, medicine, commerce, military service and the home. The objective of the study was to present the current state of the art on the harmful effects of low-frequency airborne ultrasound on people, especially in occupational settings. The scientific literature search was performed using accessible medical and other databases (WOS, BCI, CCC, DRCI, DIIDW, KJD, MEDLINE, RSCI, SCIELO and ZOOREC), and the obtained results were then hand-searched to eliminate non-relevant papers. This review includes papers published in 1948-2018. The potential effects of the low-frequency airborne ultrasound have been classified as auditory and non-auditory effects, including subjective, physiological, and thermal effects. In particular, already in the 1960-1970s, it was demonstrated that ultrasonic exposure, when sufficiently intense, appeared to result in a syndrome involving nausea, headache, vomiting, disturbance of coordination, dizziness, and fatigue, and might cause a temporary or permanent hearing impairment. However, since that time, not too much work has been done. Further studies are needed before any firm conclusions can be drawn about the auditory and non-auditory effects of low-frequency airborne ultrasound. Int J Occup Med Environ Health. 2020;33(4):389-408.
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PMID:Impact of very high-frequency sound and low-frequency ultrasound on people - the current state of the art. 3240 75