Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0012833 (
dizziness
)
9,689
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Objective:
Myelodysplastic syndrome/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis (
MDS
/MPN-RS-T) is a new disease entity in the 2016 WHO classification, characterized by anemia, thrombocytosis and bone marrow ring sideroblasts. We herein reported a case of
MDS
/MPN-RS-T and discuss its clinical characteristics.
Methods:
A 69-year-old woman presented to our hospital with recurrent
dizziness
and fatigue. Hematologic investigations, bone marrow analysis and genomic DNA sequencing studies were performed.
Results:
Peripheral blood testing showed normocytes anemia and thrombocytosis, and bone marrow analysis revealed hypercellular with clusters of megakaryocytes and 95% ring sideroblasts (RS). She had a normal karyotype and was found to have SF3B1 mutations. Decitabine therapy produced a clinical response and disease remission in this patient.
Conclusions:
Our report provides a definite conceptual framework for a better understanding of the characteristics of
MDS
/MPN-RS-T.
...
PMID:Clinical analysis and literature review of a case with the myelodysplastic syndrome/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis. 3265 43
