Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0012833 (dizziness)
 9,689 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The SSA-profile is a specific, self-administered questionnaire for measurement of subjective symptoms in untreated and treated hypertensives. Forty-two of the most frequently occurring symptoms among untreated and treated hypertensives have been included. Based on factor analysis, 25 of the items combine into dimensions covering the areas Emotional distress, Gastro-intestinal symptoms, Peripheral vascular symptoms, Cardiac symptoms, Sex life and Dizziness. The reliability and circulatory of the questionnaire have been established. For improved sensitivity in detecting subjective symptoms and comparability of results obtained in different studies the use of the SSA-profile provide valuable information. The questionnaire has been shown capable of describing subjective symptoms among untreated hypertensives. Currently, the questionnaire is being used in evaluating subjective symptoms among patients treated with different classes of antihypertensive agents.
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PMID:The SSA-profile, an instrument for assessment of subjective symptoms among hypertensives. 210 Mar 60

The H2-receptor antagonists which are used for ulcer therapy fall into four main structural classes. Cimetidine is an imidazole derivative; ranitidine belongs to the basically substituted furans, famotidine is a member of the guanidinothiazole group; and roxatidine belongs to the aminoalkylphenoxy series. Famotidine is the most potent, selective H2-receptor antagonist yet available for ulcer therapy. On a weight basis, famotidine is approximately eight times more potent than ranitidine and 40 times more potent than cimetidine. Cimetidine, ranitidine and famotidine are competitive antagonists, while the long-acting H2-receptor antagonists, e.g. loxtidine and lamitidine, are insurmountable H2-receptor blockers. Famotidine has a longer duration of action than either ranitidine or cimetidine. Because famotidine does not interact with cytochrome P-450 of the hepatic enzyme system, it does not appear to affect the metabolism of drugs metabolized by this system. The overall number of side-effects of the H2-receptor antagonists is in the range of 2-3% and no irreversible adverse effects are known. Famotidine has been found to be generally well tolerated. In a first post-marketing study, the number of patients with side-effects was only 0.43%. Side-effects such as headache, dizziness, constipation and diarrhoea have been observed only occasionally. Thus, famotidine is a safe and potent H2-receptor blocker of acid secretion.
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PMID:What are the differences between the H2-receptor antagonists? 290 67