Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0012833 (dizziness)
 9,689 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The efficacy of flufenamic acid (3 times/day in 200 mg doses) was tested in a double-blind crossover study, using 44 primary dysmenorrheic patients. After 3 months of use, flufenamic relieved symptoms in most patients. Associated gastrointestinal symptoms were relieved in 66% and 52% (for vomiting and diarrhea, respectively), and 28% of patients experienced cessation of pain symptoms. 4 cases of drug-induced side effects were reported: dizziness and mild dyspepsia.
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PMID:Flufenamic acid in treatment of primary spasmodic dysmenorrhoea. A double-blind crossover study. 7 92

A total of 2,716 patients attended a neurological out-patient clinic in North East England between May 1970 and May 1974. The symptomatology of 358 patients with primary psychiatric illness has been analyzed in a retrospective study. There were 172 symptom wordings and these were grouped in 18 headings. The most common symptoms were headache, dizziness and pain in the body. The presenting symptoms were analyzed with reference to age, sex, pattern of referral, diagnostic category and method of disposal. Aspects of non-organic disease in a neurological clinic are discussed.
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PMID:Primary psychiatric illness in a neurological out-patient department in North East England. An assessment of symptomatology. 14 14

Some women undergo induced abortion manifest a series of symptoms such as slower heart beats, irregular heart rate, lowered blood pressure, paleness, dizziness and profuse perspiration. These symptoms, which occur during or after the procedure, are referred to as "a symptom complex." In 1977, 400 pregnant women were studied to determine the cause of this symptom complex: 263 healthy women who received normal treatment; 32 women with heart ailments associated with early pregnancy, who received acupuncture; and 105 women whose heart rates were below 90, who were injected with 0.5 mg atropine. Virtually all of the 263 women had a slower heart rate during the procedure. 33 (12.55%) of these women exhibited the symptom complex, and of these, 23 (69.17%) had cramps, 17 (51.52%) had abdominal swelling, and 2 (6.09%) had backaches. Most of these symptoms occurred when the cervix dilated and after the suction. The duration and seriousness of the symptom complex varied from woman to woman, as did the recovery period, which ranged from 3 to 63 minutes. It was also found that: 1) of the 263 patients, 110 were first time mothers, of whom 15 (13.63%) had the symptom complex; 2) of the 221 healthy women who had abortion by suction, 32 (14.48%) had the symptom complex, while 1 (2.38%) who had abortion by pincers, had the symptom complex; 3) of the 33 women who had the symptom complex, the loss of blood ranged from 10 ml to 200 ml, with an average loss of 50 ml; 4) there appears to be no relationship between the manifestation of the symptom complex and negative pressure; 5) electrocardigrams were taken for 20 of the healthy patients, none of whom showed a quickened heart rate during or after the procedure; and 6) treatment for the symptom complex was by acupuncture or by injection of Atropine. The 32 acupuncture patients suffered only backaches and lower abdominal swelling, but relief of pain was slow. 105 patients were administered Atropine, none of whom manifested the symptom complex. Only 19 women perspired slightly and felt chilled in the limbs, while 3 were nauseous. Of the 33 symptom complex patients, 5 had Atropine, most of whose heart rates returned to normal after 2 seconds to 2 minutes, as did their dizziness, perspiration, and ashen coloring. However, it was found that if no treatment was given after the symptom complex emerged, a majority of the patients returned to normal on their own, some taking as long as an hour. It is believed the occurrence of the symptom complex is directly related to the mechanical stimulus applied to the uterus or cervix, the vigorous shrinkage of the uterus, loss of blood, and the negative pressure suction power of the uterine wall. Further a mechanical stimulus to the uterus can cause an "errant" nervous reflex that will affect the heart rate. This errant nervous reflex can be cut off by an injection of Atropine.
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PMID:[A symptom-complex during artificial abortion (author's transl)]. 26 29

Phosphate diabetes has been considered as rare and to occur almost exclusively in children. Upon examination of adult patients with rheumatic or kidney diseases it has, however, been found that the combination of hypophosphataemia and hyperphosphaturia is not so rare. This paper deals with 24 adult patients of this type, whom we have found during 6 months. Their mean serum phosphorus concentration was 0.7 mmol/l (range 0.5--0.8). Mean phosphate clearance was 31 ml/min/1.73 m2 (range 16--51). The diagnoses were myalgia, dorsalgia (n = 7), papillitis calcificans (n = 5), prostatitis or prostate accretions (n = 4), dizziness (n = 2), kidney stones, tubular defect, interstitial nephritis, medullary sponge kidney (1 case each), two patients had transplanted kidneys. Asthenia was a common additional diagnosis. The patients' complaints have been pain in the muscles, joints, bones (18 cases), tiredness (10 cases), dizziness (8 cases), shakyness, numbness, burning sensation (7 cases), tenderness in the muscles and bones ("the princess-on-the-pea syndrome") (7 cases). The most common findings upon examination were bone tenderness (13 cases), reduced manual power (8 cases), positive Romberg test (3 cases), slight muscle atrophy (2 cases), waddling gait (2 cases). The most common findings encountered in the laboratory, besides hypophosphataemia and hyperphosphaturia, were high pH in the urine, hyperaminoaciduria, and phosphate crystals in dried urine.
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PMID:Mild phosphate diabetes in adults. 30 93

A controlled, double-blind study involving 250 women was carried out ot assess the efficacy of oral tilidine 25, 50 and 100 mg in treating postepisiotomy pain, and to offer a comparison with oral pentazocine 50 mg. All the analgesics produced significant pain relief. At peak effect tilidine 50 mg produced very similar results to pentazocine 50 mg with tilidine 25 mg producing less, and tilidine 100 mg more pain relief. These results were not, however, statistically significant. In these postdelivery ambulant patients pentazocine 50 mg and tilidine 100 mg produced at 25% incidence of side-effects, mainly dizziness and drowsiness, but tilidine 25 mg produced significant analgesia with virtually no side-effects.
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PMID:A clinical comparison of tilidine hydrochloride and pentazocine, given orally for the treatment of postoperative pain. 33 71

The efficacy and tolerance of proquazone, 900 mg, and ibuprofen, 1200 mg, were compared in a randomized, double-blind clinical trial of 6 months' duration, with 44 patients, 21 on proquazone and 23 on ibuprofen. Comparison of proquazone-treated patients with patients treated with iburofen showed a significantly better improvement , as is demonstrated by the significant differences in the Lansbury Index, in nocturnal pain, final assessment of therapeutic effect, and number of interruptions due to lack of efficacy. All differences were in favour of proquazone, proving its therapeutic superiority over ibuprofen. The side effects in the proquazone group were mainly gastrointestinal, and 2 patients broke off treatment prematurely due to diarrhoea (in one patient, lack of efficacy was a contributory cause). A third patient discontinued because of moderate nausea and dizziness. In the ibuprofen group, 4 patients discontinued because of side effects (skin eruptions, dizziness, epigastric discomfort, and one thrombocytopenia) in addition to lack of efficacy. Proquazone seems to be an effective and well tolerated anti-inflammatory analgesic.
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PMID:A long-term double-blind comparative study on proquazone (Biarison) and ibuprofen in rheumatoid arthritis. 35 39

Clinical tolerance of benzylpenicillin administered intramuscularly in doses of 2000000--3000000 units every 4--6hours (12000000 units a day) was studied in 253 patients with pneumonia. Satisfactory tolerance of sodium benzylpenicillin and pronounced painfulness at the site of injection of potassium benzylpenicillin were noted. General toxic side effects in the form of asthenia, dizziness, pain in the heart region were observed in a part of elderly patients. The benzylpenicillin serum levels after administration of 2000000 units were 6--10 times higher than those after administration of 200000 units. The efficiency of benzylpenicillin elevated doses was studied in 193 patients. In 101 of them the previous treatment with usual doses of benzylpenicillin, i. e. 200000 units every 4 hours was not sufficiently effective. The elevated doses of benzylpenicillin proved to be effective in 78 per cent of the cases, the effect being observed in all the cases with acute pneumonia, in 88.5 per cent of the cases with neglected state and in 83 per cent of the cases with chronic pneumonia. The therapeutic effect was also observed in most of the patients with benzylpenicillin resistant microflora in the sputum. On the basis of high efficiency of penicillin therapy it was concluded that gram-positive cocci played the main role in pneumonia etiology.
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PMID:[Effectiveness of the intramuscular administration of high doses of penicillin in treating pneumonia]. 37 19

Sixty patients with moderate or severe postsurgical pain were randomly divided into three equal groups for a double-blind comparison of the analgesic effectiveness of intramuscular butorphanol (2 and 4 mg) and pentazocine (60 mg). The groups were demographically similar. Pain intensity and pain relief were scored at 10, 20, 30, 60, 120, 180, and 240 minutes after administration of the drug. All treatments provided significant analgesic activity (P less than .05) within ten minutes. However, both doses of butorphanol reached their peak effect at 30 minutes, in contrast to 60 minutes for pentazocine. The duration of effect appeared somewhat longer for butorphanol, though this did not achieve statistical significance. Butorphanol (4 mg) had a significantly greater (P less than .05) analgesic effect at ten minutes than pentazocine (60 mg), and both butorphanol treatments (2 and 4 mg) were significantly better than pentazocine, according to many parameters at 20 and 30 minutes. Side effects, chiefly sleepiness and dizziness, were seen in 15% of the patients, with no significant difference between the treatment groups.
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PMID:Comparison of butorphanol and pentazocine as postoperative analgesics. 37 1

A comparison was made of the relief of pain after operation, obtained following the i.v. administration of buprenophrine and pethidine in 60 patients with lower abdominal incisions. No difference could be detected between the maximum analgesia produced by eigher drug, but analgesia following buprenorphine appeared to last about four times as long as that following pethidine. When the drugs were compared on a "dose per body weight" basis the results supported a ratio of potency in the order of 1 : 200 in favour of buprenorphine. Vomiting, drowsiness and dizziness were less frequent following buprenorphine, but a similar frequency of nausea was observed with both agents. Marked miosis occurred 5--10 min after the i.v. injection of buprenorphine, but no serious side-effects were observed with either drug. The i.v. injection of buprenorphine, but no serious side-effects were observed with either drug. The i.v. administration of buprenorphine appeared to be effective in the management of pain after operation in patients with lower abdominal incisions.
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PMID:A comparison of buprenorphine and pethidine for immediate postoperative pain relief by the i.v. route. 66 36

A 14 year old girl developed persistent headache of 6 weeks duration, which she described as a feeling of pressure, accompanied by dizziness, nausea and vomiting. Her EEG showed focal slow waves arising from the right temporo-occipital region. All other investigations were negative. Other medication was ineffective but she responded well to standard anticonvulsant therapy, and her EEG abnormality became minimal. In a case with focal slowing and pain and other handicapping symptoms, which do not respond to other remedies, a trial of antiepileptic medication is indicated even in the absence of clinical seizures and/or EEG evidence of seizure activity.
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PMID:Focal cerebral dysrhythmia--presenting as headache: report of a case. 72 71


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