Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0012833 (dizziness)
 9,689 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Anticholinergic syndrome (AS) due to accidental poisoning is exceptional. Mandragora contains a high concentration of atropine, hiosciamine and scopolamine. We have evaluated 15 patients with AS due to poisoning by Mandragora autumnalis, distributed in two family groups. The latency period since the ingestion was 1-4 hours (Means = 2.7 +/- 0.9). The clinical features corresponded to an AS of variable severity. All patients had blurred vision and dryness of mouth, nine (60%) had difficult micturition, nine dizziness, nine headache, eight (53%) vomit, two difficult swallowing and two abdominal pain. There was no correlation between the latency period and the clinical severity. Blushing, areactive mydriasis and tachycardia were found in all, dry skin and mucosae in 14 (93%), hyperactivity/hallucination in 14 and agitation/delirium in nine (60%). One patient developed a florid psychotic episode. Prostigmine (2-6 mg) was administered to 11 patients and physostigmine (0.5-2 mg) to six. The time until a definite response was observed was variable (3-36 hours). The patients treated with physostigmine had a better reversal of the psychoneurological symptoms. Mandragora was identified intermingled with chard [correction of stalwort] (Beta vulgaris) and spinach (Spinacia oleracea) leaves, and atropine and hiosciamine were identified.
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PMID:[Atropine poisoning by Mandragora autumnalis. A report of 15 cases]. 208 9

Using self-rating questionnaires, 63 patients with social phobia but without a history of spontaneous panic attacks reported on their symptoms and traits, and on the development of their social phobia. The anxiety responses were composed of many symptoms (median = 14) of marked intensity, with blushing, trembling, cognitive difficulties, communication difficulties, and fears of the impression they make on others as cardinal symptoms. In contrast to the symptom pattern seen in spontaneous panic attacks, dizziness, chest discomforts, and difficulty in getting air were infrequent. The acute responses were generally followed by prolonged reactions with depressed mood, lowered self-esteem, and increased fears of similar situations. Most often the anticipatory anxiety was both intense and of long duration. Marked childhood traits of insecurity were reported by some patients, but these traits did not seem to be a general forerunner of the social phobia. Most patients had a gradual onset of the disorder between the age of ten and twenty, with increasing traits of social insecurity and anxiety responses developing simultaneously, during a period when a group of healthy controls reported that their insecurity was decreasing.
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PMID:Core symptom pattern of social phobia. 916 88