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Query: UMLS:C0012833 (dizziness)
 9,689 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Gonorrhea treatment has become a problem in most parts of the world and valid recommendations regarding treatment are an important control tool. In Central African Republic genital gonorrhea is one of the most common communicable diseases. In 1981 Penicillinase Producing Neisseria Gonorrhea (PPNG) was 1st isolated and, in spite of control measures, its prevalence reached 12% by the end of 1982. Effective and inexpensive treatment regimens are now needed as an alternative to the Procain Penicillin + Probenicid regimen currently in use. Since its introduction, many authors in industrialized countries have reported excellent results with Thiamphenicol (TAP) in the treatment of gonococal infections, particularly in the single dose oral treatment. Gonococcal infections caused by Penicillinase Producing Neisseria gonorrhea (PPNG) also responded favorably to the antibiotic. However, few careful studies were done in Africa. This study evaluates the efficacy of TAP compared with the standard regimen of Aqueous Procain Penicillin + Probenicid in the treatment of uncomplicated genital gonorrhea in men in Central African Republic. 380 such cases were used. Patients with coexisting genital ulcers and those treated with antimicrobics within the last 2 weeks were excluded. Gram stained smears were examined and a urethral swab was taken and cultured on a modified Thayer Martin medium. Blood specimens were collected for VDRL and TPHA tests. During a 3-month period 338 patients were treated with a positive pretreatment culture for N. gonorrhea. 242 (71.6%) presented at follow-up, with similar follow-up rates in both treatment groups (25 mg. Thiamphenicol and Aqueous Procain Penicillin G. + 1g. Probenicid). All failures but 1 in the APPG treatment group were due to PPNG infections. All of those cases were treated with Thiamphenicol regimen, 4 were cured and 6 lost for follow-up. Of 12 PPNG infections treated with Thiamphenicol, only 1 failed treatment and was cured with spectinomycin. Only few and mild side effects (diarrhea or dizziness) resulted from treatment. Thiamphenicol in single oral regimen is a low cost, effective therapy for uncomplicated gonococcal infection in males in the Central African Republic and may become potentially one of the recommended regimens if the prevalence of PPNG continues to increase.
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PMID:Thiamphenicol in treatment of genital gonorrhoeae in Central African Republic. 1234 Jan 81