Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0012833 (dizziness)
 9,689 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The pendular test was used to study turning sensations in 31 patients and 24 test persons. A steering wheel was attached to the pendular chair, and persons were asked to turn against chair rotation. Chair movement, steering wheel and horizontal vestibular nystagmus were computer-analysed. The correlation between the cumulogram of slow nystagmus phases and steering wheel rotations was evaluated. The values of the steering wheel and eye movements were calculated. It could be shown that the compensation of the pendular chair by the aid of the steering wheel was symmetric in healthy persons, in spite of the presence of spontaneous nystagmus. In patients with dizziness, no symmetric reaction was recorded.
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PMID:[Compensatory vestibular performance and rotation perception]. 387 92

A series of 22 patients complaining of disorders of equilibrium or hearing thought to be due to Central Nervous System (CNS) dysfunction has been studied. Data were obtained for electronystagmography (ENG), horizontal directionalization (HD), the staggered spondee word test (SSW), brainstem auditory evoked responses (BSER) and the Chocholle test of binaural interaction of pure tones (CH). The central ENG abnormalities found were spontaneous central vestibular nystagmus, paroxysmal central positional nystagmus, gaze paretic nystagmus, impaired optokinetic nystagmus, impaired smooth pursuit eye movements and impaired fixation-suppression of caloric nystagmus. HD results showed a weak link with hearing loss (HL). The central ENG abnormality most closely associated with impairment of HD was abnormal smooth pursuit eye movements. No significant relationship could be established between any two of the tests studied. The limited localizing value of the tests is discussed together with the contribution they make towards the diagnosis of the patient complaining of dizziness.
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PMID:Electronystagmography and horizontal directionalization. 649 94

Among 587 children at an age from 5 to 14 years, examined in the university clinic of O.R.L. Essen in a 10 years period because of dizziness, 201 times the subjective sensations could be objectified by a vestibular nystagmus. After elimination of all cases with a pathologic ear state 39 times a posture or positioning nystagmus was recorded. The examination was regularly effected by a systematic search for spontaneous and provoked nystagmus by Frenzel's luminous glasses and was completed by an experimental excitability test of the labyrinth according to Hallpike. The nystagmus findings are divided form analytically in transitory directional appointed, irregular and regular direction changing posture resp. positioning nystagmus with and without latency or contrary course. An etio-pathogenetic explanation is given.
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PMID:[Transitory postural and positional nystagmus in children and its diagnostic significance]. 663 43

We report the case of a 67-year-old man who suffered a traumatic unilateral peripheral vestibular injury subsequent to an unrelated prior cerebellar infarction that occurred at least 2 years earlier. The patient's clinical course was marked by poor compensation for his peripheral vestibular loss. Four months after his vestibular injury, his symptoms of dizziness had not resolved. He had a spontaneous vestibular nystagmus, and laboratory testing indicated an asymmetric semicircular canal-ocular reflex. The otolith-ocular reflex, tested using off-vertical axis rotation, also was asymmetric but had a preserved modulation component. Visual-vestibular interaction and semicircular canal-otolith interaction were normal. An MRI indicated preservation of the flocculo-nodular lobe but infarction of the pyramis and uvula. Taken together, the findings in this case suggest that despite structural and functional preservation of the flocculo-nodular lobe, an anatomic region often labeled the "vestibulo-cerebellum", a lesion of the cerebellum that can impair CNS compensation for a unilateral peripheral lesion in humans.
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PMID:Vestibular compensation in a patient with a cerebellar infarction. 910 77

Among older patients we regularly find those who complain of a hazy tinnitus in combination with vertigo, giddiness, and dizziness. They also report a reduced state of alertness. Objectively, these patients exhibit an increase in latencies of experimentally evoked vestibular nystagmus and of auditory brainstem-evoked potentials. This group of patients is affected by the disorder known as slow-brainstem syndrome. By evaluating therapeutic responses, we noted especially in this group that a combination of cocculus (picrotoxin), conium (Coniine), amber, and petroleum (Vertigoheel) has a "tune-up" effect on the brainstem. With regular therapy using this drug regimen, we observed a normalization of the distorted latencies of the statoacoustic pathways, followed by disappearance of the symptoms. Our explanation for this phenomenon suggests an improvement in the vestibular, ocular, and acousticocortical pathway synchronization in such older patients. We present some models.
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PMID:The slow-brainstem syndrome: tinnitus and dyssynchrony in the central nervous system. 1822 89