Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0012833 (dizziness)
 9,689 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Thirty male patients with nongonococcal urethritis and 7 female patients nongonococcal cervicitis were treated with 200 mg doxycycline (DOXY) daily over a period of 7 days. The microbiological cure rate in infections with C. trachomatis was 92.9% with the clinical effectiveness rate being 92.9%. The clinical effectiveness rate in nonchlamydial urethritis was 63.6%. There were no statistically demonstrable difference in clinical outcome between the group of the C. trachomatis positive patients and the C. trachomatis negative patients, both treated with DOXY. Side effects were observed in 2 cases (5.4%) who complained of gastrointestinal disorder, but no dizziness was observed.
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PMID:[Clinical evaluation of doxycycline in the treatment of Chlamydia trachomatis infections]. 409 52

In a randomized, double-blind, dose-ranging study, single oral doses of rosoxacin were used to treat 126 patients with uncomplicated genital or anorectal gonorrhea. Neisseria gonorrhoeae was eradicated from 5 (28%) of 18 men treated with 100 mg, compared with 101 (94%) of 108 men and women treated with 200 mg, 300 mg, or 400 mg (P less than 0.001). Susceptibility to rosoxacin was determined for 6 pretreatment gonococcal isolates from these patients and for 194 stored clinical isolates; 296 (98.7%) of these 300 isolates, including 10 strains of penicillinase-producing N. gonorrhaeae, required a minimal inhibitory concentration of less than or equal to 0.062 microgram/ml. Urethral or cervical infection with Chlamydia trachomatis coexisted with gonococcal infection in 14 (22%) of 63 patients and persisted in 7 of 10 patients treated with rosoxacin. Postgonococcal urethritis developed in 11 (34%) of 32 men who were monitored for 12 to 30 days. Sixty-four subjects (51%) developed transient dizziness, drowsiness, altered visual perceptions, or other symptoms suggestive of central nervous system dysfunction after treatment with rosoxacin, but these symptoms were not clearly dose related. Rosoxacin in doses of greater than or equal to 200 mg appears to be effective for single-dose treatment of uncomplicated gonorrhea, but further studies of its possible central nervous system toxicity are indicated.
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PMID:Treatment of uncomplicated gonorrhea with rosoxacin. 679 24