Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0012833 (dizziness)
 9,689 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Carbamazepine is a commonly prescribed anticonvulsant medication that affects various levels of the nervous system. We report a case of temporary sensorineural hearing loss in a patient after overdosing with 36 g of carbamazepine. Six days after the overdose, the patient complained of bilateral hearing loss and tinnitus. Audiograms revealed a 30- to 40-dB sensorineural hearing loss bilaterally. Another audiogram 2 weeks later showed a complete recovery in both ears accompanied by a clinical resolution in audiovestibular symptoms. Carbamazepine is used to treat partial and generalized seizures, trigeminal neuralgia, and bipolar illness. Adverse effects are not common but most frequently include dizziness, drowziness, nausea, and skin rashes; rare complications are agranulocytosis, bradycardia, and heart block. Documented hearing loss as a side effect of carbamazepine has not been reported, to our knowledge.
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PMID:Carbamazepine-induced sensorineural hearing loss. 1003 90

Human immunodeficiency virus (HIV) protease inhibitors are prone to drug interactions with other agents. As individuals with HIV infection live longer, the clinical significance of many interactions is becoming recognized. A 51-year-old man with HIV infection who was receiving extended-release nifedipine developed symptomatic orthostasis and heart block after starting antiretroviral therapy that included nelfinavir. He experienced dizziness, fatigue, and hypotension and developed complete heart block with a junctional escape rhythm. Electrocardiogram abnormalities abated within 24 hours of discontinuing antiretroviral therapy. The patient developed orthostatic symptoms after restarting nelfinavir. He was switched successfully to an efavirenz-based regimen. Subsequent administration of antiretroviral therapy containing ritonavir and indinavir with extended-release nifedipine resulted in recurrence of his orthostatic symptoms. Discontinuation of atenolol, and nifedipine dosage reduction by 50% were effective in managing his orthostatic changes. Careful monitoring by clinicians is necessary when concomitant administration of HIV protease inhibitors are prescribed with other agents that are metabolized through the cytochrome P450 system.
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PMID:Symptomatic orthostasis with extended-release nifedipine and protease inhibitors. 1238 81

The aim of the study was to assess the situation with implantation of cardiac pacemakers and to critically evaluate the possibility of this method of treatment. The study was conducted from 2001 to 2007. Data on a total of 211 operations were included in the study. There were 121 (57.3%) male patients, mean age 69.7 years, and 90 (42.7%) female patients, mean age 74.5 years. Total number of operations increased from 18 in 2001 to 24 in 2002, 28 in 2003, 38 in 2004, 38 in 2005, 30 in 2006 and 35 in 2007. Primo implantation was carried out in 196 (92.9%) cases. The following types of pacemakers were used: VVI in 79 (40.3%), VVIR in 73 (37.2%), DDD in 7 (3.6%), DDDR in 18 (9.2%), VDD in 17 (8.7%) and AAIR in 2 (1.0%) cases. ECG indication was second degree heart block in 40, third degree heart block in 86, chronic atrial fibrillation with bradyarrhythmia in 57, sick sinus syndrome in 27 cases and trifascicular block in one case. The symptoms included dizziness in 126, syncope in 52, dyspnea in 45, bradycardia in 12, chest pain in 3 and cerebral dysfunction in 2 cases. In conclusion, our patients now receive appropriate treatment within a shorter time, thus reducing pressure upon large cardiac surgery centers. However, efforts should be continuously invested in approaching European standards of artificial pacemaker implantation.
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PMID:The first seven years of implantation of permanent cardiac pacemakers in a small urban community in central Croatia. 1938 70

A 32 year-old patient presented with a two-week duration of fever with hepato-splenomegaly with dizziness spells for two days. The patient was found to have HIV and to be leptospira positive. Electrocardiogram showed complete heart block which disappeared after antibiotic treatment. Our case is unique because a combination of HIV, leptospirosis and complete heart block has never before been described in literature.
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PMID:A case of complete heart block in a patient with HIV and leptospirosis. 2049 Oct 21

A 65-years-old female presented with features suggesting acute coronary syndrome, initially as non STEMI and later as classical Prinzmetal's angina. While being treated she also had recurrent episodes of dizziness and cardiac arrest due to complete heart block and asystole. These episodes occurred while on nitroglycerine infusion and were not accompanied by chest pain or ST-T segment changes. Coronary angiography revealed evidence of reversible multi-vessel coronary spasm. Electrophysiological studies were normal. She was treated with nitrates and calcium blockers and a permanent pacemaker implantation.
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PMID:Coronary vasospasm presenting as Prinzmetals angina and life threatening Brady-arrhythmia independently at different times. 2063 48

A 29-year-old man was referred to the emergency department with a complaint of abdominal pain and dizziness. He had experienced two previous syncopal episodes. His family history revealed that his mother and his two uncles had received permanent pacemaker implantation. His initial heart rate was 49 beats per minute. The electrocardiography (ECG) showed atrial flutter and right bundle branch block (RBBB) with left anterior fascicular block (LAFB). On admission, 24-hour Holter showed ventricular pause up to 16 seconds during syncope. Radio frequency catheter ablation (RFCA) of atrial flutter was performed. The ECG revealed bifascicular block (RBBB and LAFB) and first-degree atrioventricular block. He received a permanent pacemaker implantation. His brother's and his sister's ECGs also showed trifascicular block and the pedigree showed autosomal dominant inheritance. This patient was diagnosed with a progressive familial heart block (PFHB) type I. This would be the first report of a PFHB type I case documented in Korea.
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PMID:Progressive familial heart block type I in a korean patient. 2173 70

An 82-year-old white woman was seen in the emergency department (ED) after ingesting 400 mg of flecainide in an attempt to treat an episode of dizziness and palpitations that occurred while she was gardening. Consequently, she developed bradycardia, hypotension, and complete heart block. In addition to supportive care, she also received sodium bicarbonate, atropine, calcium gluconate, and dopamine in an effort to reverse the heart block. The patient continued to remain in heart block and was sent to the cardiac catheterization laboratory for placement of an external pacing wire, which stabilized the patient. After further evaluation, a permanent pacemaker was implanted during her admission. External pacing wires may be useful in the treatment of complete heart block in cases of flecainide poisoning when a patient is unresponsive to drug therapy provided in the ED.
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PMID:Irreversible third-degree heart block and pacemaker implant in a case of flecainide toxicity. 2381 74

A 52 year old patient presented with orthostatic dizziness and syncope caused by postural heart block. When the patient was supine, atrioventricular conduction was normal but when she assumed the upright posture she developed advanced atrioventricular block rapidly progressing to complete heart block. We are presenting a case of syncope caused by orthostatic heart block.
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PMID:Reflex syncope manifesting as orthostatic complete heart block. 2497 9

A 94-year-old woman presented with dizziness and hypotension of 2 days' duration. She denied any syncope, presyncope, or angina. She had received a permanent pacemaker 12 years previously for the management of complete heart block (CHB), but she failed to program it. Twelve-lead electrocardiography revealed CHB with ventricular escape rhythm (40/min), so we inserted a temporary pacemaker. Anteroposterior chest X-ray showed trachea, aortic arch, and severe mitral valve calcification. Tracheal calcification is usually seen after 40 years old without clinical importance. However, it is seen in patients with renal failure, metastases, and prolonged use of warfarin as well as in pregnancy.(1) (-) (3).
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PMID:Senile Calcification of the Trachea, Aortic Arch, and Mitral Annulus: An Incidental Finding on Chest X-Ray. 2698 13

A 77-year-old woman presented with a 3-week history of low grade fever, appetite loss and dizziness. An electrocardiogram showed complete heart block. Echocardiography demonstrated severe aortic valve stenosis and a mass of probable vegetation 2 cm in diameter on the atrioventricular septum in the right atrium (RA), but no obvious intra-cardiac fistula. There was no growth of organism in blood cul tures. In the 4th week after admission, a harsh and continuous cardiac murmur was detected for the 1st time. Portable echocardiography revealed disappearance of the mass in the RA, and showed an intra-cardiac shunt from the left ventricle( LV) to RA. The shunt was closed by autologous pericardial patch form LV side and directly with mattress suture form RA side during the emergency operation. The aortic valve was replaced with bio-prosthetic valve (SJM Trifecta 19 mm). No organism was detected in the excised tissue, but antibiotics were continued for 2 months until a permanent pacemaker was inserted.
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PMID:[Acquired Left Ventricular-right Atrial Communication due to Infective Endocarditis;Report of a Case]. 2747 71


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