Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0012833 (dizziness)
 9,689 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A case of metastasis of thyroid cancer into the cardiac cavity is described. A 73-year-old female suffered from sudden chest pain, dyspnea and dizziness and admitted to a local clinic on emergency. A diagnosis of bilateral multiple pulmonary infarction was made by lung perfusion scintigraphy. However, a mass migrating between the right atrium and the right ventricle across the tricuspid valve was demonstrated by echocardiography, and the patient was referred to us under a diagnosis of myxoma complicated with pulmonary infarction. Incision of the right atrium disclosed a gelatinous mass resembling frog eggs, attached to the right ventricle side of the anterior cusp of the tricuspid valve and swinging across the orifice of the valve. The gross lesion was removed completely. Since the histological diagnosis was clear cell carcinoma, no surgery was performed on the pulmonary artery. Postoperative re-examination by ultrasonography and CT revealed thyroid cancer as the primary lesion.
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PMID:[Surgical resection of cardiac metastasis of thyroid cancer--a case report]. 203 39

Recombinant human TSH (rhTSH) (thyrotropin alfa, Genzyme Co.) has been developed to improve the management of patients with differentiated thyroid cancer, who need radioiodine (131I) for treatment or follow-up diagnosis. Data available from published series involving approximately 500 patients prove that rhTSH is safe and that mostly unspecific non-severe side effects may occur (e.g. nausea, vomiting, headache or fatigue and dizziness). Tumor swelling which has been occasionally observed after rhTSH injection is a phenomenon well known from the past attributed to endogenous TSH stimulation after thyroid hormone withdrawal (THW) and can be prevented or alleviated by concomitant administration of glucocorticoids. The absorbed dose to the tumor after preparation of 131I therapy with rhTSH as compared to THW is not statistically different. The radiation dose to the blood and the remainder, however, is significantly lower if rhTSH is used instead of THW which is a strong argument in favor of rhTSH. Most importantly, the quality of life (QOL) after rhTSH is preserved as compared to THW where symptoms of hypothyroidism significantly impair QOL. Last but not least, more convenient scheduling of patients and shorter duration of time to be spent in the radioprotective ward are further arguments in favor of rhTSH.
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PMID:Recombinant human thyrotropin: safety and quality of life evaluation. 2301 71

We present 2 patients with pituitary metastases from thyroid carcinoma-the first from anaplastic thyroid carcinoma and the second from follicular thyroid carcinoma. The first patient, a 50-year-old lady, presented with 2-week history of hoarseness of voice, dysphagia, dyspnoea, and neck swelling. Imaging revealed metastatic thyroid cancer to lymph nodes and bone. Histology from surgery confirmed anaplastic thyroid cancer. She was found to have pituitary metastases postoperatively when she presented with nonvertiginous dizziness. She subsequently underwent radiotherapy and radioiodine treatment but passed away from complications. The second patient, a 65-year-old lady, presented with loss of appetite and weight with increased goitre size and dyspnoea. Surgery was performed in view of compressive symptoms and histology confirmed follicular thyroid carcinoma. Imaging revealed metastases to bone, lung, and pituitary. She also had panhypopituitarism with hyperprolactinemia and diabetes insipidus. She received radioiodine therapy but eventually passed away from complications.
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PMID:Thyroid carcinoma with pituitary metastases: 2 case reports and literature review. 2568 65