Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0012739 (disseminated intravascular coagulation)
 8,673 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A method for continuous monitoring of microthrombosis in the lungs is described. After injection of labelled fibrinogen and platelets the accumulation of these blood constituents was estimated during experimental disseminated intravascular coagulation (DIC) by radioactivity measurement on the body surface. By optimizing the measuring geometry of a single hole collimator for scintillation probes a high relative efficiency was attained and a defined area of the lung was viewed. This method allows recording of the trapping of fibrin and platelets in the lungs in experimental DIC and investigations on the pharmacological control of this condition.
 ...
PMID:Monitoring of microthrombosis in experimental animals by continuous recording of 125I-fibrin deposits and 51Cr-labelled platelets in the lungs. 742 33

Chronic subdural hematoma (CSDH) is one of the most common clinical entities in daily neurosurgical practice. The diagnosis and treatment are well established, but recurrence, complications, and factors related to these problems, especially in the elderly, are not completely understood. This study evaluated the clinical features, radiological findings, and surgical results in a large series of the patients treated at the same institution. 500 consecutive patients (359 men and 141 women) with CSDH were treated by burr hole craniostomy with closed system drainage from January 1987 through February 1999. Causes, clinical and computed tomographic findings, surgical results, re-expansion of brain after surgery, and hematoma recurrence were statistically analyzed to elucidate the potential risks of CSDH. Most patients (89.4%) had good recovery, 8.4% showed no change, and 2.2% worsened. Six patients (1.2%) died, three due to disseminated intravascular coagulation. Recurrence of hematoma was recognized in 49 patients (9.8%), at 1 to 8 weeks (3.5 +/- 1.9 weeks) after the first operation. The brain re-expansion rate at one week after operation was 45.0 +/- 21.4% in patients with hematoma recurrence and significantly lower than 55.3 +/- 19.1% in patients without recurrence (p < 0.001). Old age, pre-existing cerebral infarction, and persistence of subdural air after surgery were significantly correlated with poor brain re-expansion (p < 0.001). Twenty-seven patients (5.4%) suffered postoperative complications, of which 13 cases were acute subdural hematoma caused by incomplete hemostasis of the scalp wound and four cases were tension pneumocephalus. Careful hemostasis and complete replacement of subdural hematoma by normal saline to prevent influx of air into the subdural space will further improve the surgical outcome for patients with CSDH.
 ...
PMID:Surgical treatment of chronic subdural hematoma in 500 consecutive cases: clinical characteristics, surgical outcome, complications, and recurrence rate. 1156 47

We treated two cases of a subdural hematoma associated with dural metastasis of gastric cancer, from which both patients died. Case 1: A 60-year-old female patient was hospitalized with a diagnosis of type 4 gastric cancer of the antrum. The patient suddenly collapsed, and, subsequently, left hemiplegia and a depressed level of consciousness were noted. A head computed tomography (CT) scan revealed a subdural hematoma with midline shift. The patient was diagnosed with chronic subdural hematoma and underwent emergency burr hole irrigation. Case 2: A 73-year-old man was diagnosed with type 4 gastric cancer and a total gastrectomy plus splenectomy were performed together with dissection of the N1 and N2 lymph node groups (D2 dissection) in March 2006 (T3, N2, P0, H0, INFgamma, ly3, v0, por2). Postoperative adjuvant chemotherapy was performed using oral TS-1; following tests revealed no recurrence in the abdomen. In December 2006, gingival bleeding was noted with disseminated intravascular coagulation (DIC) and 10 days later, the patient was hospitalized with chief complaints of impaired consciousness and anorexia. CT scan revealed a right subdural hematoma with a midline shift. The patient was diagnosed with chronic subdural hematoma and underwent emergency burr hole irrigation and drainage. The dural biopsy of the two cases revealed adenocarcinoma noted in the dural blood vessel. Special staining revealed CEA-positive adenocarcinoma, and a diagnosis of the dural metastasis of gastric cancer was made. These patients' level of consciousness significantly improved postoperatively. However, DIC developed concurrently, and the patients died on the 13th and 14th postoperative day, respectively.
 ...
PMID:Subdural hematoma associated with dural metastasis of gastric carcinoma: report of two cases. 1821 41

A 44-year-old man visited a nearby hospital because of severe headache. Brain MRI revealed a subdural hematoma, and he was transferred to the Department of Neurosurgery of our hospital. Burr hole surgery was performed on the second day of hospitalization because of an enlargement of the hematoma. Laboratory data on admission showed the presence of a disseminated intravascular coagulation(DIC). Bone marrow aspiration revealed metastases of signet ring cell carcinoma, and abdominalCT showed gastric cancer. He was diagnosed as having DIC with bone marrow metastases of advanced gastric cancer. Despite anti-DIC therapy and blood transfusion, his systemic bleeding tendency was not improved. The neurosurgeon therefore consulted with a palliative care team. Since the patient was still young, we considered that he should be treated with anti-cancer drugs. At first, his family did not accept chemotherapy because they were pessimistic about his prognosis. However, after he regained his consciousness, we were able to perform sequential MTX and 5-FU therapy with the consent of the patient and his family. The therapy was successful, and he recovered from DIC and was discharged on the 57th hospital day.
 ...
PMID:[A case of gastric cancer accompanied by disseminated carcinomatosis of bone marrow with DIC, and subdural hematoma successfully treated with sequential methotrexate and 5-fluorouracil therapy]. 2167 95

In situ planar deformation measurement using two-dimensional digital image correlation (2D-DIC) and a fixed camera has been fully investigated in many published works and widely used for various applications. However, in certain special cases (e.g., long-term deformation monitoring of engineering structures, or deformation measurement of a specimen subjected to uncommon loading), it is very difficult or impossible to carry out in situ deformation measurement using 2D-DIC, and necessitates ex situ 2D-DIC measurements for a repositioned specimen or using a relocated camera. To achieve accurate measurements, the error sources of ex situ 2D-DIC measurements should be identified and minimized, and the strain accuracy of ex situ 2D-DIC measurements should be quantified. In this work, the potential error sources of ex situ 2D-DIC measurements are first discussed in detail. Then, to mitigate the errors associated with these issues, an ultra-stable 2D-DIC system combining the idea of active imaging and a well-designed bilateral telecentric lens is established, which is invariant to the potential variations in ambient lighting and the possible small out-of-plane motions in object surface and/or image plane. The established ultra-stable 2D-DIC system is first compared with the regular 2D-DIC setup in determining the surface strains of an unstrained sample. Then, ex situ residual stress measurement using the hole-drilling technique and the established 2D-DIC system was conducted and compared with the applied ones. The results of this work confirm that the accuracy of ex situ 2D-DIC deformation measurements using the proposed system is of high fidelity, and can be used for accurate deformation measurement in practical ex situ tests.
...
PMID:Accurate ex situ deformation measurement using an ultra-stable two-dimensional digital image correlation system. 2508 83